Resonance-Induced Ablation (RITA): A New Alternative to Oncological Therapy

Resonance-Induced Ablation (RITA): A New Alternative to Oncological Therapy | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Resonance-Induced Ablation (RITA): A New Alternative to Oncological Therapy Fernando Medina Cunha, Cesar Mello This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7285375/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Conventional tumor ablation techniques—such as RFA, HIFU, cryoablation, and IRE—are limited by anatomical targeting and nonspecific energy delivery, often resulting in incomplete treatment or collateral damage, especially in multifocal or infiltrative tumors. \textit{Resonance-Induced Tumor Ablation (RITA)} is a nonthermal, spectrum-resolved technique that achieves deterministic disintegration by targeting the intrinsic eigenfrequencies ( \omega_k ) of malignant tissue. Energy is delivered only when local strain exceeds the viscoelastic rupture threshold ( \epsilon(x,t) \geq \epsilon_{\mathrm{crit}} ), with automatic cessation upon modal collapse. In simulations (FEM, ( n=12 )) and gel phantom experiments (( n=9 )), RITA achieved: No off-target effects were detected in adjacent inclusions spaced as close as 5~mm, confirming spatial selectivity driven purely by spectral decoupling. Multifocal ablation occurred sequentially, with each lesion extinguished at its own resonant mode without temporal overlap. Real-time spectral feedback, implemented via phase-locked tracking, enabled fully autonomous actuation and self-termination, without reliance on external sensors. These results position RITA as a deterministic, frequency-specific ablation method, effective even in anatomically irregular or histologically diverse tumor environments. Biological sciences/Cancer Physical sciences/Engineering Health sciences/Medical research Health sciences/Oncology Physical sciences/Physics resonance-induced ablation nonthermal tumor therapy spectral fingerprint solid tumors precision oncology Full Text Additional Declarations No competing interests reported. Supplementary Files pointbypointresponse.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7285375","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":500217771,"identity":"5b580da1-6be8-4297-8bff-78517247d13b","order_by":0,"name":"Fernando Medina Cunha","email":"","orcid":"","institution":"Centro de Oncologia Campinas","correspondingAuthor":false,"prefix":"","firstName":"Fernando","middleName":"Medina","lastName":"Cunha","suffix":""},{"id":500217773,"identity":"3cf26a00-6d22-44e2-a6a4-06e7090ebc14","order_by":1,"name":"Cesar Mello","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABCUlEQVRIiWNgGAWjYDADPnYGxgcQJg+RWtiYGZgNSNbCJkGUFv729oefKxi2ybExMx+r+FFRF80v3XtM8geDTb68A3YtEmfOGEueYbhtzMbMlnaz58zh3JlzzqVJ8zCkWW48gF2LgUQOg2QDw+3ENmYes9uMbQdyN9zIMZNmYDhsYNiAQ4v888c/gVrqQVqKGdvqwFqADsOjRYLBDGRLAhtQCzNjGzNYiwQPUIs8Du9LnMkxs2wwuG3YxsyWLAnxyxljax6DNAMDnCF2/PHNhorb8vzszQc/AEMst1+6x/DmjwobA3kcDoM6D8ViBhYJkIjBAXxaUN3KwPwBROO3ZRSMglEwCkYQAADk1FKIFw9dywAAAABJRU5ErkJggg==","orcid":"","institution":"Cosmo Physics Organization","correspondingAuthor":true,"prefix":"","firstName":"Cesar","middleName":"","lastName":"Mello","suffix":""}],"badges":[],"createdAt":"2025-08-03 20:53:03","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7285375/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7285375/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":93574633,"identity":"4883a57a-e99d-4e7c-bf99-bf2ce32e3185","added_by":"auto","created_at":"2025-10-15 09:17:14","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2533964,"visible":true,"origin":"","legend":"","description":"","filename":"ResonanceInducedTumorAblationRITAV2.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7285375/v1_covered_4840649f-2b36-4832-9730-5d9d5c5ef2eb.pdf"},{"id":89413963,"identity":"2314ef75-7ab1-4c73-bb07-d13db0773f53","added_by":"auto","created_at":"2025-08-19 16:53:05","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":31286,"visible":true,"origin":"","legend":"","description":"","filename":"pointbypointresponse.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7285375/v1/907134287a292299ac96566d.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Resonance-Induced Ablation (RITA): A New Alternative to Oncological Therapy","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"resonance-induced ablation, nonthermal tumor therapy, spectral fingerprint, solid tumors, precision oncology","lastPublishedDoi":"10.21203/rs.3.rs-7285375/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7285375/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Conventional tumor ablation techniques—such as RFA, HIFU, cryoablation, and IRE—are limited by anatomical targeting and nonspecific energy delivery, often resulting in incomplete treatment or collateral damage, especially in multifocal or infiltrative tumors.\n\\textit{Resonance-Induced Tumor Ablation (RITA)} is a nonthermal, spectrum-resolved technique that achieves deterministic disintegration by targeting the intrinsic eigenfrequencies \\( \\omega_k \\) of malignant tissue. Energy is delivered only when local strain exceeds the viscoelastic rupture threshold \\( \\epsilon(x,t) \\geq \\epsilon_{\\mathrm{crit}} \\), with automatic cessation upon modal collapse.\nIn simulations (FEM, \\( n=12 \\)) and gel phantom experiments (\\( n=9 \\)), RITA achieved:\nNo off-target effects were detected in adjacent inclusions spaced as close as 5~mm, confirming spatial selectivity driven purely by spectral decoupling. Multifocal ablation occurred sequentially, with each lesion extinguished at its own resonant mode without temporal overlap. Real-time spectral feedback, implemented via phase-locked tracking, enabled fully autonomous actuation and self-termination, without reliance on external sensors. 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