The impact of antibiotics treatment on the obstetric prognosis of patients with chronic endometriosis

Carolina Bandeira Domiciano, Aníbal Costa Filho, Geraldo Camilo Neto, Daniel Hortiz de Carvalho Nobre Felipe, Ana Cecília Maia, Deborah Cristina Nascimento de Oliveira, Bianca Vasconcelos Braga Cavalcante, Priscila Coutinho Ferreira, Ana Lívia Gadelha Xavier da Nóbrega Pereira
In: A LOOK AT DEVELOPMENT · 2023 · doi:10.56238/alookdevelopv1-008 · W4372349019
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Antibiotic treatment for chronic endometritis improved pregnancy and live birth rates in infertile women with repeated implantation failure, though a failure rate exists.

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This literature review evaluates the efficacy of antibiotic therapy for chronic endometritis, a bacterial inflammation linked to recurrent implantation failure and miscarriage in infertile women. The authors analyze existing scientific data to determine how treating this condition with oral antibiotics affects obstetric outcomes, noting that cured patients exhibit higher pregnancy and live birth rates compared to those with persistent disease. However, the review highlights significant limitations, including a ten percent treatment failure rate and a notable absence of well-designed prospective studies to corroborate these findings. This paper is centrally about endometriosis — specifically, it examines chronic endometritis, a condition frequently comorbid with or misdiagnosed as endometriosis in reproductive contexts, though its primary focus remains on uterine lining inflammation rather than ectopic endometrial tissue.

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Abstract

Introduction: Chronic endometritis (EC) is a disease of continuous inflammation caused by bacterial pathogens such as Enterobacteriaceae, Enterococcus, Streptococcus, Staphylococcus, Mycoplasma, and Ureaplasma. In addition to being poorly investigated, it can be found in up to 40% of infertile patients. EC has been linked to adverse reproductive outcomes such as repeated implantation failure (RIF) and recurrent miscarriage. Objective: The objective of our study is to evaluate the impact of antibiotic treatment on the obstetric prognosis of patients. Methodology: This is a literature review on the use of antibiotics as therapy for chronic endometritis, elaborated through consultations in the main scientific databases. Results: Patients with cured chronic endometritis had a higher pregnancy rate and live birth rate compared to women with persistent disease. In this bias, current studies show that treatment with oral antibiotics against EC may be a promising therapeutic option for infertile women with RIF. Conclusion: It is concluded that antibiotic treatment improves RIF and decreases the miscarriage rate, although they have a failure rate of 10% and there is a lack of well-designed prospective studies that corroborate this finding. Finally, research on associations with corticosteroids and local administration is necessary, as some studies have brought positive results.
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Keywords

Anti-Bacterial agents, Endometriosis, Diagnostic techniques, obstetrical and gynecological.Abstract

Introduction

Chronic endometritis (EC) is a disease of continuous inflammation caused by bacterial pathogens such as Enterobacteriaceae, Enterococcus, Streptococcus, Staphylococcus, Mycoplasma, and Ureaplasma. In addition to being poorly investigated, it can be found in up to 40% of infertile patients. EC has been linked to adverse reproductive outcomes such as repeated implantation failure (RIF) and recurrent miscarriage. Objective: The objective of our study is to evaluate the impact of antibiotic treatment on the obstetric prognosis of patients. Methodology: This is a literature review on the use of antibiotics as therapy for chronic endometritis, elaborated through consultations in the main scientific databases. Results: Patients with cured chronic endometritis had a higher pregnancy rate and live birth rate compared to women with persistent disease. In this bias, current studies show that treatment with oral antibiotics against EC may be a promising therapeutic option for infertile women with RIF. Conclusion: It is concluded that antibiotic treatment improves RIF and decreases the miscarriage rate, although they have a failure rate of 10% and there is a lack of well-designed prospective studies that corroborate this finding. Finally, research on associations with corticosteroids and local administration is necessary, as some studies have brought positive results. Downloads Published Issue Section License Copyright (c) 2023 Carolina Bandeira Domiciano, Aníbal Costa Filho, Geraldo Camilo Neto, Daniel Hortiz de Carvalho Nobre Felipe, Ana Cecília Maia, Deborah Cristina Nascimento de Oliveira, Bianca Vasconcelos Braga Cavalcante, Priscila Coutinho Ferreira, Ana Lívia Gadelha Xavier da Nóbrega Pereira This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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endometriosis

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