The 17Beta-Hydroxysteroid Dehydrogenase Type 1 Gene Polymorphism and Endometriosis

Mohammed Sayed Mohammed, Hany Hassan Kamal
In: Journal of Endometriosis and Pelvic Pain Disorders · 2013 · vol. 5(3) , pp. 116–119 · doi:10.5301/je.5000161 · W2056684072
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Abstract

Purpose Endometriosis is a chronic, painful disease that affects the female genital tract with unknown definite etiology, though there are multiple theories that try to explain its etiology. Genetic causes are suggested in the most widely accepted theories, and this study examined the association between the HSD17B1 gene polymorphism and endometriosis and its severity. Methods Twenty-five patients with clinical suspicion of endometriosis confirmed by laparoscopic examination were admitted to the Gynecology and Obstetrics Department in the Minia University Hospital, and 25 women were enrolled as controls. All subjects underwent genetic analysis for the HSD17B1 gene polymorphism. Results There were significant associations between genotyping analysis of the cases and controls: G/G, A/G and A/A distributions among the cases were 8%, 60% and 32%, respectively, while in controls, they were 60%, 32% and 8%, respectively (p = 0.002, p = 0.05 and p = 0.03, respectively). There were no associations between the HSD17B1 gene polymorphism and severity of endometriosis. Conclusion Genetic analysis of the HSD17B1 gene polymorphism showed it to have an important role in the etiology of endometriosis. Extensive further studies are recommended for further genes that may be associated with endometriosis.

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endometriosis

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