The role of E-cadherin and CA_(125) in the diagnosis of endometriosis
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Serum E-cadherin levels are elevated in endometriosis patients, offering higher specificity than CA125 for diagnosis, and potentially serving as a new biomarker.
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Abstract
Objective:To investigate the role of E-cadherin and CA125 in the diagnosis of endometriosis.Methods:The level of E-cadherin and CA125 in the serum of endometriosis patients were compared with that of the control group and normal group using the enzyme linked immunosorbent assay and radio-immunity.Results:The level of E-cad in serum of endometriosis patients was significantly higher than that of control and normal group.With the evaluation of E-cad,the sensitivity and specificity was 79.3% and 80.7%,respectively.While that of CA125 was 65.2% and 51.9%,respectively.Then,when both E-cad and CA125 were used to predict the diagnosis of endometriosis,the specificity increased to 84.1%.Conclusion:In the serum of endometriosis,the level of E-cad is increased.The specificity of the increased level of serum E-cad is higher than that of CA125 to diagnose endometriosis.So,E-cad may become a biological maker of endometriosis.
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- last seen: 2026-06-10T17:14:06.276822+00:00
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