Besides Abrogating an Unusual Case of Eating Induced Mid-Epigastric Pain, Treatment with Dextroamphetamine May Help to Increase Oocyte Reserve in A Young Teenage Girl Possibly Heading for Premature Menopause

The increased cellular permeability syndrome where inflammatory conditions related to unwanted irritants infusing into various tissues related to local permeability issues is etiologic in many different types of abdominal pain. These abdominal conditions and many other pain syndromes have been completely abrogated by treatment with the dopamine agonist dextroamphetamine sulfate. The most frequent cause of diminished oocyte reserve (DOR) and premature ovarian failure (POF) is increased permeability of the ovaries leading to inflammatory damage and loss of eggs. A 14-year-old teenager whose mother had premature ovarian failure, brought her 14-year-old daughter for evaluation of severe pain with eating. Pediatric gastroenterologists were stumped as to the cause of abdominal pain. As part of her evaluation, we obtained a serum anti-mullerian hormone (AMH) level which was found to be low normal even for an adult. She was treated with dextroamphetamine which completely eliminated her pain from eating for 2 years now. We were hoping that this dopamine agonist could slow down the rate of egg loss to give her time to advance to a late teenager rather than consider egg freezing in someone so young. We were very surprised that after 2 years not only did her serum AMH not drop any further but actually increased to a level of 2.5 ng/mL which is at a much more comfortable level of egg reserve. This case suggests that reducing the cause of ovary inflammation by the use of dopamine agonist may not only retard egg depletion but even allow more oogenesis to occur.