Abhängigkeit zwischen ovarieller Suppression und Rückgang der Endometriose-Implantate bei LHRH-Analog(Buserelin)-Therapie

H. Ochs, U. Cirkel, Karl-Werner Schweppe, H. P. G. Schneider
In: Gynäkologie und Geburtshilfe 1988 · 1989 · pp. 941–942 · doi:10.1007/978-3-642-74784-7_484 · W1986808820
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This study investigated the relationship between ovarian suppression and the regression of endometriosis implants during LHRH-analog (Buserelin) therapy.

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The paper examines the relationship between ovarian suppression and regression of endometriosis implants during 6 months of treatment with the LHRH analog buserelin. It is motivated by reports that some patients still have histologically viable endometriotic tissue after the cycle and that estradiol (E2) serum levels can occasionally remain above the follicular range. The key finding is that the regression of implants depends on the degree of ovarian suppression achieved during therapy, linking incomplete suppression with persistence of viable implants. The paper’s results are directly about endometriosis treatment with buserelin and specifically addresses how ovarian suppression relates to endometriosis implant regression. This paper is centrally about endometriosis — it investigates how ovarian suppression during buserelin therapy relates to the reduction of endometriosis implants.

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Zusammenfassung Die Wirksamkeit von LHRH-Analogen in der Therapie der Endometriose kann als erwiesen gelten [2, 4]. Trotzdem wird in einigen Fällen noch vitales Endometriosegewebe am Ende eines 6monatigen Behandlungszyklus histologisch nachgewiesen. Unter der Therapie können ferner gelegentlich über dem follikulären Bereich liegende Estradiol (E2)-Serumspiegel beobachtet werden. Im folgenden wird daher untersucht, inwieweit eine Beziehung zwischen ovarieller Suppression und Endometrioseimplantat-Rückgang besteht. Similar content being viewed by others Literatur American Fertility Society (1979) Classification of endometriosis. Fertil Steril 32: 633 Cirkel U, Schweppe K-W, Ochs H, Schneider HPG (1986) Effect of LH-RH agonist therapy in the treatment of endometriosis (German experience). In: Rolland R, Chadha DR, Willemsen WNP (eds) Gonadotropin Down-Regulation in Gynecological Practice. Alan R. Liss, New York, pp 189–199 Jänne O, Kauppila A, Kokko E, Lantto T, Rönnberg L, Vihko R (1981) Estrogen and progestin receptors in endometriotic lesions: Comparison with endometrial tissue. Am J Obstet Gynecol 141: 562–566 Lemay A, Maheux R, Faure N, Jean C, Fazekas ATA (1984) Reversible hypogonadism induced by a luteinizing hormone releasing hormone (LH-RH) agonist (Buserelin) as a new therapeutic approach for endometriosis. Fertil Steril 41: 863–871 Schweppe K-W, Wynn RM, Beller FK (1984) Ultrastructural comparison of endometriotic implants and eutopic endometrium. Am J Obstet Gynecol 148: 1024–1030 Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 1989 Springer-Verlag Berlin Heidelberg About this paper Cite this paper Ochs, H., Cirkel, U., Schweppe, KW., Schneider, H.P.G. (1989). Abhängigkeit zwischen ovarieller Suppression und Rückgang der Endometriose-Implantate bei LHRH-Analog(Buserelin)-Therapie. In: Ludwig, H., Krebs, D. (eds) Gynäkologie und Geburtshilfe 1988. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74784-7_484 Download citation DOI: https://doi.org/10.1007/978-3-642-74784-7_484 Publisher Name: Springer, Berlin, Heidelberg Print ISBN: 978-3-642-74785-4 Online ISBN: 978-3-642-74784-7 eBook Packages: Springer Book Archive

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