Mechanisms of control of prolactin release in response to apprehension stress and anesthesia-surgery stress

B Corenblum, Bernard Corenblum, Patrick J. Taylor, P J Taylor
Fertility and sterility · 1981 · vol. 36(6) , pp. 712–715 · doi:10.1016/s0015-0282(16)45912-1 · PMID:7308513 · W2413963556
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This study examined prolactin release mechanisms in women undergoing surgical stress, finding that distinct pharmacological agents differentially modulate hormone responses to preoperative apprehension versus anesthesia-surgery stress.

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Abstract

The response of prolactin to stress may not be controlled by a single mechanism. This study was designed to measure the prolactin response in the human female to two reproducible stresses: the apprehension (A) prior to surgery (laparoscopy and hysteroscopy) and the stress of the anesthesia-surgery (AS). Attempts to modify the release of prolactin was made by pharmacologic means. Thirty-eight normally menstruating women served either as controls or received histamine (H1), serotonin, opioid, or dopamine receptor-blocking agents and the prolactin response was measured. The release of prolactin to AS was blunted by higher-dose of opioid and by dopamine antagonists. The A release of prolactin was enhanced by the dopaminergic antagonist and blunted by the other three agents. It was concluded that the mechanism for the stress-induced release of prolactin may vary depending upon the nature of the stress.

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MeSH descriptors

Prolactin Stress, Physiological Stress, Psychological Adult Anesthesia Anxiety Anxiety Chlorpheniramine Chlorpheniramine Cyproheptadine Cyproheptadine Female Humans Naloxone Naloxone Pimozide Pimozide Prolactin Stress, Physiological Stress, Psychological

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