BRIDGE: A Novel Integrated Motor–Cognitive Screening Protocol for Early Detection of Mild Cognitive Impairment — A Pilot Feasibility Study

BRIDGE: A Novel Integrated Motor–Cognitive Screening Protocol for Early Detection of Mild Cognitive Impairment — A Pilot Feasibility Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Method Article BRIDGE: A Novel Integrated Motor–Cognitive Screening Protocol for Early Detection of Mild Cognitive Impairment — A Pilot Feasibility Study Marco Sorrentino, Michelle Castenetto, Federico Inglese, Cozzi Francesca, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-9279121/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Mild Cognitive Impairment (MCI) represents a transitional clinical state between normal aging and dementia, characterized by measurable cognitive decline without significant functional impairment. Increasing evidence suggests that motor performance—particularly under dual-task conditions—reflects early executive dysfunction and may serve as a sensitive biomarker of incipient neurodegeneration. Therefore, exploring novel motor and cognitive dual-task approaches, including those involving both upper and lower limb functions, may offer enhanced diagnostic precision for early-stage cognitive decline compared to traditional screening methods Objective : To evaluate the feasibility, acceptability, and preliminary discriminative performance of the BRIDGE protocol, an integrated motor–cognitive screening tool. This pilot study aims to address the challenges in early MCI detection, which is often misdiagnosed in primary care settings due to multidimensional assessment barriers. Methods : Prospective pilot feasibility study integrating cognitive (MoCA), motor (gait speed), and dual-task paradigms (TUG-DT, TTHP-DT). Outcomes include feasibility metrics and preliminary discriminative capacity. Conclusion: The BRIDGE protocol may provide a scalable and cost-effective screening strategy and function as a gatekeeping tool for advanced diagnostics. This approach could facilitate earlier identification of individuals at risk for cognitive decline, thereby enabling timely intervention and management strategies. Developmental Neuroscience Cognitive Neuroscience Neurology Physical Medicine & Rehab BRIDGE score MCI AD Alzheimer's Disease PAPA Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-9279121","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Method Article","associatedPublications":[],"authors":[{"id":615242832,"identity":"d12398f6-8bfb-4d9d-acde-2763bf7442aa","order_by":0,"name":"Marco 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This pilot study aims to address the challenges in early MCI detection, which is often misdiagnosed in primary care settings due to multidimensional assessment barriers.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: Prospective pilot feasibility study integrating cognitive (MoCA), motor (gait speed), and dual-task paradigms (TUG-DT, TTHP-DT). Outcomes include feasibility metrics and preliminary discriminative capacity.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e The BRIDGE protocol may provide a scalable and cost-effective screening strategy and function as a gatekeeping tool for advanced diagnostics. 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