Drivers underpinning the malignant transformation of giant cell tumour of bone
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Abstract
The rare benign giant cell tumour of bone (GCTB) is defined by an almost unique G34W oncohistone mutation in the H3.3 histone gene. Here we reveal the genomic and methylation patterns underlying the rare clinical phenomena of benign metastases and malignant transformation of GCTB.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00