The effect of biochemical markers in first-trimester screening test in predicting gestational diabetes mellitus

Abstract Objective Early diagnosis and treatment are critical to minimize the complications of gestational diabetes mellitus (GDM). Therefore, the present study aimed to determine whether first-trimester screening test biochemical markers could be an early predictive model for GDM. Material and Method: This retrospective study was performed by accessing the electronic media data of 116 pregnant women who underwent first-trimester screening tests at the 11th-14th weeks of gestation and were diagnosed with GDM at the 24th-28th weeks and 65 pregnant women who did not receive this diagnosis. Demographic characteristics of GDM and control groups, first-trimester screening test biochemical markers, oral glucose tolerance test (OGTT), and hemoglobin A1c values were recorded, and intergroup comparison was made. Results There was no statistically significant difference between the groups regarding first-trimester biochemical markers (p > 0.05). A negative correlation was determined between PAPP-A and free hCG multiple of median (MoM) values and OGTT fasting value (p < 0.05). Conclusion In this study, we concluded that first-trimester biochemical markers could not predict the development of GDM.