Contribution of Matrix Metalloproteinase-7 Genotypes to Endometriosis Risk in Taiwan

Hung-Ju Chien, Hung‐Ju Chien, Yun-Chi Wang, Wen-Shin Chang, Yi‐Hsien Hsieh, Yi-Hsien Hsieh, Yen-Fang Liu, Ya-Chen Yang, Ya–Chen Yang, Jaw‐Chyun Chen, Jaw-Chyun Chen, DA-Tian Bau, Da‐Tian Bau, Chia-Wen Tsai
Anticancer research · 2024 · vol. 44(7) , pp. 3051–3058 · doi:10.21873/anticanres.17118 · PMID:38925847 · W4400060463
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that the MMP7 rs11568818 GG genotype is associated with increased endometriosis risk in a Taiwanese population.

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Abstract

BACKGROUND/AIM: The activity and expression of matrix metalloproteinase-7 (MMP7) have been found to be upregulated in the late stages of endometriosis. However, the contribution of MMP7 genotype to endometriosis has seldom been examined. This study aimed to investigate the role of MMP7 promoter A-181G (rs11568818) and C-153T (rs11568819) genotypes in determining personal susceptibility to endometriosis in a Taiwanese cohort. PATIENTS AND METHODS: In this hospital-based case-control study, MMP7 genotypes were analyzed in 153 endometriosis and 636 individuals without endometriosis using typical polymerase chain reaction-restriction fragment length polymorphism methodology. RESULTS: The statistical analysis revealed that MMP7 rs11568818 genotypes were differentially distributed between the endometriosis and control groups (p for trend=0.0048). Specifically, the MMP7 rs11568818 homozygous variant GG was associated with endometriosis risk compared to the wild-type AA genotype (OR=4.59, 95% CI=1.46-14.48, p=0.0136). However, the MMP7 rs11568818 heterozygous variant AG was not associated with endometriosis risk (OR=1.57, 95% CI=0.97-2.53, p=0.0854). The frequency of than variant allele G of MMP7 rs11568818 was 12.7% in the endometriosis group, significantly higher than the 7.2% observed in the control group (OR=1.90, 95% CI=1.27-2.82, p=0.0021). CONCLUSION: MMP7 rs11568818 GG genotype was found to be a novel marker for endometriosis risk in Taiwanese.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Genetic Predisposition to Disease Genetic Predisposition to Disease Genetic Predisposition to Disease Genetic Predisposition to Disease Genetic Predisposition to Disease Genetic Predisposition to Disease Genetic Predisposition to Disease Genotype Genotype Genotype Genotype Genotype

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