Biochemical Profiling of Inflammatory and Metabolic Markers in Reproductive-Age Women with Endometriosis

Huma Hameed, Hanana Hameed, Aaisha Qadir, Tariq Hussain, Waqas Qurshi, Arifa Inayat, Nosheen Sikandar Baloch
In: Pakistan Journal of Medical and Health Sciences · 2023 · vol. 17(12) , pp. 356–359 · doi:10.53350/pjmhs020231712356 · W4413494155
Observational OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-21 ⓘ

This study found that reproductive-age women with endometriosis exhibit elevated inflammatory markers, insulin resistance, and dyslipidemia compared to healthy controls, with correlations between biochemical abnormalities and disease severity.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-03 · read from full text ⓘ

This cross-sectional study evaluated serum levels of inflammatory and metabolic markers in 120 reproductive-age women, comparing 80 with laparoscopically confirmed endometriosis against 40 healthy controls. The researchers found that patients with endometriosis exhibited significantly elevated levels of hs-CRP, IL-6, and TNF-α, alongside increased fasting insulin, glucose, triglycerides, and HOMA-IR values compared to the control group. Statistical analysis revealed positive associations between disease severity and both inflammatory markers and insulin resistance, indicating a link between biochemical abnormalities and clinical presentation. This paper is centrally about endometriosis — specifically investigating its association with systemic inflammation and metabolic dysfunction in South Asian women.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Background: Endometriosis is a chronic gynecological disorder characterized by the ectopic presence of endometrial tissue, commonly presenting with pelvic pain, dysmenorrhea, and infertility. Increasing evidence suggests that endometriosis is a systemic disease involving chronic inflammation and metabolic dysfunction, yet data from South Asian populations remain limited. Objective: To assess the biochemical profile of inflammatory and metabolic markers in reproductive-age women with endometriosis and compare them with healthy controls. Methods: This cross-sectional study was conducted from May 2022 to February 2023 at Bolan Medical Complex Hospital and the Gynecology and Obstetrics Department, Unit 3, Civil Hospital Quetta. A total of 120 women aged 18–45 years were enrolled, including 80 women with laparoscopically confirmed endometriosis and 40 healthy controls. Serum levels of hs-CRP, IL-6, TNF-α, fasting insulin, glucose, lipid profile, and HOMA-IR were measured. Statistical analysis was performed using SPSS version 26.0. Results: Inflammatory markers were significantly elevated in women with endometriosis: hs-CRP (6.72 ± 1.18 vs. 3.25 ± 0.94 mg/L), IL-6 (7.94 ± 2.43 vs. 3.37 ± 1.12 pg/mL), and TNF-α (13.12 ± 3.45 vs. 8.24 ± 2.21 pg/mL) (all p < 0.001). Metabolic disturbances were also noted, with increased fasting insulin, glucose, and HOMA-IR values. Triglycerides were elevated and HDL-C levels were significantly reduced in the endometriosis group. Correlation analysis showed positive associations between disease severity and both inflammatory markers and insulin resistance. Conclusion: Endometriosis in reproductive-age women is associated with systemic inflammation and metabolic dysfunction, with a clear correlation between biochemical abnormalities and disease severity. These findings support the need for a multidisciplinary approach in the diagnosis and management of endometriosis, integrating metabolic and inflammatory monitoring. Keywords: Endometriosis, inflammation, metabolic dysfunction, HOMA-IR, cytokines, reproductive-age women, hs-CRP, IL-6, TNF-α.
Full text 2,507 characters · extracted from oa-doi-fallback · 6 sections · click to expand

Background

Endometriosis is a chronic gynecological disorder characterized by the ectopic presence of endometrial tissue, commonly presenting with pelvic pain, dysmenorrhea, and infertility. Increasing evidence suggests that endometriosis is a systemic disease involving chronic inflammation and metabolic dysfunction, yet data from South Asian populations remain limited.

Objective

To assess the biochemical profile of inflammatory and metabolic markers in reproductive-age women with endometriosis and compare them with healthy controls.

Methods

This cross-sectional study was conducted from May 2022 to February 2023 at Bolan Medical Complex Hospital and the Gynecology and Obstetrics Department, Unit 3, Civil Hospital Quetta. A total of 120 women aged 18–45 years were enrolled, including 80 women with laparoscopically confirmed endometriosis and 40 healthy controls. Serum levels of hs-CRP, IL-6, TNF-α, fasting insulin, glucose, lipid profile, and HOMA-IR were measured. Statistical analysis was performed using SPSS version 26.0.

Results

Inflammatory markers were significantly elevated in women with endometriosis: hs-CRP (6.72 ± 1.18 vs. 3.25 ± 0.94 mg/L), IL-6 (7.94 ± 2.43 vs. 3.37 ± 1.12 pg/mL), and TNF-α (13.12 ± 3.45 vs. 8.24 ± 2.21 pg/mL) (all p < 0.001). Metabolic disturbances were also noted, with increased fasting insulin, glucose, and HOMA-IR values. Triglycerides were elevated and HDL-C levels were significantly reduced in the endometriosis group. Correlation analysis showed positive associations between disease severity and both inflammatory markers and insulin resistance.

Conclusion

Endometriosis in reproductive-age women is associated with systemic inflammation and metabolic dysfunction, with a clear correlation between biochemical abnormalities and disease severity. These findings support the need for a multidisciplinary approach in the diagnosis and management of endometriosis, integrating metabolic and inflammatory monitoring.

Keywords

Endometriosis, inflammation, metabolic dysfunction, HOMA-IR, cytokines, reproductive-age women, hs-CRP, IL-6, TNF-α. Downloads How to Cite Issue Section License Copyright (c) 2023 Hanana Hameed, Aaisha Qadir, Tariq Hussain, Waqas Qurshi, Arifa Inayat, Nosheen Sikandar Baloch This work is licensed under a Creative Commons Attribution 4.0 International License.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisdysmenorrheainfertility

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cited by (1)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK