Oral microbiome pattern in hematological pediatric malignancies: need for investigating

Several evidence suggest the role of oral microbiota in metabolic, immuno-mediated, oncological diseases. In pediatric population, aberration in oral microbiota were investigated in relation to host and environmental factors, pre, during and post chemotherapy. However, limited information can be obtained on effective microbiota pattern in leukemia pediatric patients and on its role related to local and systemic complications. The aim of our study is to conduct a critical review of the literature on this issue, providing to suggest future researches planning.  KEYWORDS:  oral microbiome, acute lymphoblastic leukemia, ALL, hematologic disease, childhood leukemia, oral dysbiosis, microbiota.