Morphological characteristics of endometriosis vesicles.

Annelyn Torres-Reverón (5650028), Leslie L. Rivera-Lopez (5963024), Idhaliz Flores (5650034), Caroline B. Appleyard (5650037)
2018 · doi:10.1371/journal.pone.0197698.g006 · W6885789749
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This study investigated the effects of antalarmin, a corticotropin-releasing hormone receptor 1 antagonist, on endometriosis progression in a rat model. The researchers compared an antalarmin-treated group against a vehicle control group, measuring outcomes such as the percentage of implants developing into vesicles, total vesicle weight, average volume, and area. Results indicated that antalarmin treatment significantly reduced the formation of vesicles and decreased their overall size and weight compared to controls. This paper is centrally about endometriosis — specifically examining how CRHR1 antagonism inhibits the morphological development of endometriotic lesions in vivo.

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Abstract

(A) The percent of implants that developed into vesicles was significantly lower in the antalarmin treated group (n = 20) compared to the vehicle control group (n = 20). (B) The total weight of all vesicles per rat was smaller for the antalarmin treated rats. (C) The average vesicle volume per rat was significantly smaller for the antalarmin treated group compared to the vehicle control group. (D) The average vesicle area per rat was significantly smaller in the antalarmin group compared to the vehicle group. (E) Vesicles that developed were classified by grade based on a scale by size showing that the individual vesicles in the antalarmin treated group tended to be smaller (grade 2) or not develop at all (grade 1). * p< 0.05, ** p< 0.01.
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Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis Fig 6 Morphological characteristics of endometriosis vesicles. (A) The percent of implants that developed into vesicles was significantly lower in the antalarmin treated group (n = 20) compared to the vehicle control group (n = 20). (B) The total weight of all vesicles per rat was smaller for the antalarmin treated rats. (C) The average vesicle volume per rat was significantly smaller for the antalarmin treated group compared to the vehicle control group. (D) The average vesicle area per rat was significantly smaller in the antalarmin group compared to the vehicle group. (E) Vesicles that developed were classified by grade based on a scale by size showing that the individual vesicles in the antalarmin treated group tended to be smaller (grade 2) or not develop at all (grade 1). * p< 0.05, ** p< 0.01.

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endometriosis

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