Histopathological and immunohistochemical characterization of spontaneously occurring uterine deciduomas in young adult rats.

Yoshizawa K, Emoto Y, Kinoshita Y, Kimura A, Norihisa Uehara, Yuri T, Shikata N, Tsubura A
Journal of toxicologic pathology · 2013 · doi:10.1293/tox.26.61 · PMID:23723570 · PMC3620216
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This paper characterizes spontaneous uterine deciduomas in young rats as non-neoplastic lesions arising from interstitial cells, noting their potential utility as historical controls in toxicity and pharmacological studies.

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This study characterized spontaneously occurring uterine deciduomas in two young adult female rats, identifying firm white nodules located at the base of unilateral uterine horns. Histopathological analysis revealed that these lesions consisted of three distinct regions containing proliferating epithelioid decidual cells, spindle-shaped transitional cells, and pleomorphic mesometrial cells arranged in sheet-like patterns. Immunohistochemical staining demonstrated strong positivity for proliferating cell nuclear antigen, vimentin, progesterone receptors, and muscular markers, while estrogen receptor alpha was absent in the antimesometrial region. The authors concluded that these rare tumor-like nodules represent nonneoplastic decidual reactions of endometrial interstitial cells with benign biological behavior, potentially serving as historical controls in toxicology studies. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Uterine deciduomas were found in two female virgin rats, a 15-week-old Lewis rat and a 7-week-old Sprague-Dawley rat. The firm white nodules were located at the base of unilateral uterine horns and were approximately 6 mm and 4 mm in diameter. Histopathologically, the nodules were composed of three areas, each with a distinct type of proliferating cells: large epithelioid decidual cells with round nuclei, prominent nucleoli and abundant eosinophilic cytoplasm (antimesometrial region); compact spindle-shaped cells with oval nuclei and vacuolar cytoplasm (transitional region); and pleomorphic and spiny cells with round to oval nuclei and compact eosinophilic cytoplasm (mesometrial region). These cells proliferated in sheet-like arrangements and transformed into the other types of cells located in surrounding regions. Immunohistochemically, proliferating cells in all regions were strongly positive for proliferating cell nuclear antigen. The proliferating cells were positive for vimentin, and large decidual cells were positive for common acute lymphoblastic leukemia antigen 10, a marker of uterine interstitial cells. Large decidual cells were positive for α-smooth muscle actin and desmin, suggesting differentiation into muscular cells. Progesterone receptor was expressed in all cell types; however, estrogen receptor α was not expressed in the antimesometrial region. These extremely rare tumor-like nodules represent nonneoplastic lesions referred as decidual reactions of endometrial interstitial cells, and their biological behavior is that of a space-occupying benign tumor in young rats. Our cases might provide information as a historical control in toxicity and pharmacological studies in rats.
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Case Reports Histopathological and Immunohistochemical Characterization of Spontaneously Occurring Uterine Deciduomas in Young Adult Rats 2013 Volume 26 Issue 1 Pages 61-66 Details Abstract Uterine deciduomas were found in two female virgin rats, a 15-week-old Lewis rat and a 7-week-old Sprague-Dawley rat. The firm white nodules were located at the base of unilateral uterine horns and were approximately 6 mm and 4 mm in diameter. Histopathologically, the nodules were composed of three areas, each with a distinct type of proliferating cells: large epithelioid decidual cells with round nuclei, prominent nucleoli and abundant eosinophilic cytoplasm (antimesometrial region); compact spindle-shaped cells with oval nuclei and vacuolar cytoplasm (transitional region); and pleomorphic and spiny cells with round to oval nuclei and compact eosinophilic cytoplasm (mesometrial region). These cells proliferated in sheet-like arrangements and transformed into the other types of cells located in surrounding regions. Immunohistochemically, proliferating cells in all regions were strongly positive for proliferating cell nuclear antigen. The proliferating cells were positive for vimentin, and large decidual cells were positive for common acute lymphoblastic leukemia antigen 10, a marker of uterine interstitial cells. Large decidual cells were positive for α-smooth muscle actin and desmin, suggesting differentiation into muscular cells. Progesterone receptor was expressed in all cell types; however, estrogen receptor α was not expressed in the antimesometrial region. These extremely rare tumor-like nodules represent nonneoplastic lesions referred as decidual reactions of endometrial interstitial cells, and their biological behavior is that of a space-occupying benign tumor in young rats. Our cases might provide information as a historical control in toxicity and pharmacological studies in rats. © 2013 The Japanese Society of Toxicologic Pathology Favorites & Alerts Recently viewed articles

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