Polygonatum sibiricum polysaccharide affects growth performance and immune response in cyclophosphamide-induced immunosuppressed chickens

Background: This study aims to identify the effects of dietary Polygonatum sibiricum polysaccharide (PP) on growth performance and blood parameters in immunosuppressed chickens induced by cyclophosphamide (CY). Results: The results showed that PP enhanced the growth performance and immune response in chickens treated with cyclophosphamide characterized by increasing relative weight of thymus, total antioxidant capacity (T-AOC), superoxidase dismutase (SOD), albumin (ALB), immunoglobulin M (IgM), and antibody titers of Newcastle disease (ND) and avian influenza (H9), and decreasing feed conversion ratio (FCR) and malondialdehyde (MDA) level. Conclusions: PP enhanced chickens’ growth performance via improving antioxidant ability and alleviating CY-induced immunological stress.