THE INFLUENCE OF ENDOCANNABINOID SYSTEM ON WOMEN REPRODUCTION

Dana Popescu‐Spineni, D M Popescu-Spineni, L Guja, Guja L, C M Cristache, Cristache CM, Pop-Tudose ME, M E Pop-Tudose, Munteanu AM, A M Munteanu
Acta endocrinologica (Bucharest, Romania : 2005) · 2022 · vol. 18(2) , pp. 209–215 · doi:10.4183/aeb.2022.209 · PMID:36212249 · PMC9512370 · W4304117736
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⚙ AI-generated summary by claude@2026-06, 2026-06-14 ⓘ

The endocannabinoid system, including its receptors and endocannabinoids, plays a crucial role in all stages of reproduction and associated pathologies, with phytocannabinoids also influencing these processes.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-14 · read from full text ⓘ

This paper is a narrative overview describing how the endocannabinoid system, including cannabinoid receptors (CB1, CB2) and endocannabinoids (anandamide and 2-arachidonylglycerol), is implicated across multiple stages of women’s reproduction, from folliculogenesis and oogenesis through fertilization, implantation, and pregnancy progression. It highlights that endocannabinoid signaling may contribute to the physiopathology of several reproductive disorders, explicitly including endometriosis, ectopic pregnancy, miscarriage, preeclampsia, endometrial cancer, and polycystic ovary syndrome, and it notes that recent research focuses on reproductive tissue dysfunction via endocannabinoid pathways. The authors also discuss phytocannabinoids and medical versus recreational cannabis use, framing the need for updated information for clinicians and public health professionals, with the caveat that the article is not presented as original research. Relevance to endometriosis: the paper explicitly lists endometriosis among reproductive conditions in whose physiopathology the endocannabinoid system is implicated, though the main focus is a broad overview of endocannabinoid biology and cannabis in women’s reproduction rather than endometriosis specifically.

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Abstract

The discovery of the cannabinoid receptors CB1 and CB2 in 1990 and 1993, respectively, as well as of the two main endocannabinoids, anandamide in 1992 and 2-arachidonylglycerol in 1995, was an important step in identifying the strongest homeostatic system in the human body, namely the endocannabinoid system. Ever since, research has highlighted the crucial part played by this system in all the reproduction stages: folliculogenesis, spermatogenesis, oogenesis, fecundation, transport of the egg through the fallopian tubes, blastocyte implantation and pregnancy progression, as well as its implications in the physiopathology of the reproductive system: in endometriosis, ectopic pregnancy, miscarriage, preeclampsia, endometrial cancer, polycystic ovary syndrome, ovarian cancer. A special attention must be paid to the phytocannabinoids, natural components originating especially from the Cannabis plant inflorescences, whose medical effects are well-established nowadays with also acting on the receptors of the endocannabinoid system. The most recent research mainly focuses on the reproductive dysfunctions and disorders of the reproductive tissues, respectively, through its action upon the endocannabinoid system. Medical cannabis is nowadays legalized in more and more countries all over the world. At the same time, recreational cannabis remains one of the most consumed drugs (in Romania the most consumed one by young adults). Therefore, it is mandatory for specialists in obstetrics and gynecology, endocrinology, public health, hygiene or for general practitioners, to permanently update their information on this subject.
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- Login - Register - Home/Current Issue - About the journal - Editorial board - Online submission - Instructions for authors - Subscriptions - Foundation Acta Endocrinologica - Archive - Contact Romanian Academy The Publishing House of the Romanian Academy ACTA ENDOCRINOLOGICA (BUC) The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List Acta Endocrinologica(Bucharest) is live in PubMed Central Journal Impact Factor - click here. This Article Services Google Scholar PubMed Acta Endocrinologica (Buc) Popescu-Spineni DM, Guja L, Cristache CM, Pop-Tudose ME, Munteanu AM The Influence of Endocannabinoid System on Women Reproduction Acta Endo (Buc) 2022, 18 (2): 209-215doi: 10.4183/aeb.2022.209 The discovery of the cannabinoid receptors CB1 and CB2 in 1990 and 1993, respectively, as well as of the two main endocannabinoids, anandamide in 1992 and 2-arachidonylglycerol in 1995, was an important step in identifying the strongest homeostatic system in the human body, namely the endocannabinoid system. Ever since, research has highlighted the crucial part played by this system in all the reproduction stages: folliculogenesis, spermatogenesis, oogenesis, fecundation, transport of the egg through the fallopian tubes, blastocyte implantation and pregnancy progression, as well as its implications in the physiopathology of the reproductive system: in endometriosis, ectopic pregnancy, miscarriage, preeclampsia, endometrial cancer, polycystic ovary syndrome, ovarian cancer. A special attention must be paid to the phytocannabinoids, natural components originating especially from the Cannabis plant inflorescences, whose medical effects are wellestablished nowadays with also acting on the receptors of the endocannabinoid system. The most recent research mainly focuses on the reproductive dysfunctions and disorders of the reproductive tissues, respectively, through its action upon the endocannabinoid system. Medical cannabis is nowadays legalized in more and more countries all over the world. At the same time, recreational cannabis remains one of the most consumed drugs (in Romania the most consumed one by young adults). Therefore, it is mandatory for specialists in obstetrics and gynecology, endocrinology, public health, hygiene or for general practitioners, to permanently update their information on this subject. Keywords: endocannabinoid system, medical cannabis, reproductive system, public health and hygiene, family medicine. Correspondence: Melania Elena Pop-Tudose MD, “Carol Davila” University of Medicine and Pharmacy, Eroii Sanitari Blvd no. 8, Bucharest, Romania, E-mail: [email protected]

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