Effects of Xiao Chaihu Tang on experimental endometriosis in rats

Aim:To investigate the effect of Xiao Chaihu Tang on treatment(endometriosis) in rats and to explore its mechanism.Methods:The rat model of endometriosis was established and was treated with Xiao Chaihu Tang,Danazol,and Xiao Chaihu Tang plus Danazol for 4 week,respectively.The height on endometriotic tissue(EOS) was evaluated by the morphonemethical method;Cyclooxygenase-2(COX-2)expression in each group of endometrium and endometriotic tissue was examined by immunohistochemistry method.Results:The reduced rate of the height of endometrial epithelium on the endometriotic tissue in the treated groups were lower than the control groups,especially in the Xiao Chaihu Tang puls Danazol group.The expression of COX-2 in the endometriotic tissue was lower than that of eutopic endometrium in the Xiao Chaihu Tang group and Xiao Chaihu Tang puls Danazol group,while Danazol group and control group were opposed to Xiao Chaihu Tang group.Conclusion:The mechanism of Xiao Chaihu Tang on the treatment endometriosis may be to decrease the COX-2 expression and reduce the prostaglandin synthesization.