Cumulus cell apoptosis changes with exposure to spermatozoa and pathologies involved in infertility

Díaz-Fontdevila M, Marina Díaz-Fontdevila, Pommer R, Ricardo Pommer, Rosita Smith, Smith R
Fertility and sterility · 2009 · vol. 91(5 Suppl) , pp. 2061–8 · doi:10.1016/j.fertnstert.2008.05.073 · PMID:18692783
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Insemination increased cumulus cell apoptosis, which was higher in poor-quality embryos and associated with endometriosis and fertilization rates, but not pregnancy.

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This prospective study investigated changes in cumulus cell apoptosis following insemination among 100 women undergoing in vitro fertilization and embryo transfer. The researchers found that exposure to spermatozoa significantly increased the apoptotic rate of cumulus cells, with higher rates observed in oocytes from cycles resulting in poor quality embryos or lower fertilization outcomes. These results indicate that cumulus cell apoptosis serves as a potential biomarker for embryo quality and fertilization success during assisted reproductive procedures. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

OBJECTIVE: To determine whether the incidence of apoptosis in mature oocyte cumulus cells changes after insemination related to infertility. DESIGN: Prospective study. SETTING: Public hospital and university. PATIENT(S): One hundred women undergoing in vitro fertilization and embryo transfer (IVF-ET). INTERVENTION(S): Collection of cumulus cells from IVF-ET cycles with different infertility etiologies. MAIN OUTCOME MEASURE(S): Detection of apoptosis in cumulus cells; fertilization, embryo quality, and pregnancy rate. RESULT(S): The incubation of cumulus-oocyte-complexes with spermatozoa led to an increase in cumulus cell apoptosis from 34.2 +/- 3.7 to 44.5 +/- 6.3%. After insemination, cumulus cells of poor quality embryos showed a statistically higher apoptotic rate versus cumulus cells of good quality embryos (61.5 +/- 6.4 vs. 40.6 +/- 3.9%). Cumulus cells arising from oocytes with >or=50% fertilization rates after insemination showed higher apoptosis rates did cumulus cells from oocytes with <50% fertilization rates (46.0 +/- 3.7 vs. 33.8 +/- 4.0%). Patients with endometriosis presented higher apoptotic rates before insemination (77.6 +/- 9.06%). Cumulus cells obtained after aspiration showed no differences in their apoptosis rates for the following factors: age of women, aspirated oocytes, estradiol level, fertilization rate, and embryo quality or pregnancy. The apoptotic profile from pregnant women was less than (but not statistically significantly different from) profiles from nonpregnant women. CONCLUSION(S): These results suggest that the incidence of apoptosis in cumulus cells is associated with exposure to spermatozoa and the cause of infertility.
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Cumulus cell apoptosis changes with exposure to spermatozoa and pathologies involved in infertility Artículo Open/ Download Publication date 2009Metadata Show full item record Cómo citar Díaz-Fontdevila, Marina Cómo citar Cumulus cell apoptosis changes with exposure to spermatozoa and pathologies involved in infertility Abstract Objective: To determine whether the incidence of apoptosis in mature oocyte cumulus cells changes after insemination related to infertility. Design: Prospective study. Setting: Public hospital and university. Patient(s): One hundred women undergoing in vitro fertilization and embryo transfer (IVF-ET). Intervention(s): Collection of cumulus cells from IVF-ET cycles with different infertility etiologies. Main Outcome Measure(s): Detection of apoptosis in cumulus cells; fertilization, embryo quality, and pregnancy rate. Result(s): The incubation of cumulus-oocyte-complexes with spermatozoa led to an increase in cumulus cell apoptosis from 34.2 ± 3.7 to 44.5 ± 6.3%. After insemination, cumulus cells of poor quality embryos showed a statistically higher apoptotic rate versus cumulus cells of good quality embryos (61.5 ± 6.4 vs. 40.6 ± 3.9%). Cumulus cells arising from oocytes with ≥50% fertilization rates after insemination showed higher apoptosis rates did cumulus cells from oocytes with < Indexation Artículo de publicación SCOPUS Identifier URI: https://repositorio.uchile.cl/handle/2250/164749 DOI: 10.1016/j.fertnstert.2008.05.073 ISSN: 00150282 Quote Item Fertility and Sterility, Volumen 91, Issue 5 SUPPL., 2018, Pages 2061-2068 Collections

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Condition tags

endometriosisinfertility

MeSH descriptors

Apoptosis Cumulus Cells Oocytes Spermatozoa Adult Adult Apoptosis Apoptosis Cumulus Cells Cumulus Cells Cumulus Cells Embryo Transfer Embryo Transfer Embryo Transfer Endometriosis Endometriosis Endometriosis Female Female Fertilization

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