Danazol induced thrombocytopenia.

Yamamoto K, Hoshiai H, Tsubaki K, Kasano Y, Shimizu K, Horiuchi A
The Tohoku Journal of Experimental Medicine · 1997 · doi:10.1620/tjem.182.249 · PMID:9362107
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Danazol induced severe thrombocytopenia in a 34-year-old woman with an endometrial cyst, as evidenced by recurrent bleeding and low platelet counts upon rechallenge.

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This case report describes a 34-year-old woman who developed severe immune thrombocytopenic purpura with gingival bleeding and purpura shortly after initiating danazol therapy for an ovarian cyst. Laboratory results showed critically low platelet counts, which normalized following treatment with methylprednisolone, but recurred rapidly upon rechallenge with the same medication. The authors diagnosed the condition as danazol-induced thrombocytopenia based on the temporal relationship between drug administration and symptom onset, as well as the positive response to steroid therapy and negative reaction to re-exposure. This paper is centrally about endometriosis — specifically the management of an endometrial cyst (endometrioma) using danazol, while documenting a rare adverse hematological effect of the treatment.

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Abstract

A 34-year-old woman with a left ovarian cyst (clinically diagnosed as endometrial cyst) was treated with 400 mg of danazol per day. On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred. Her laboratory findings were as follows: platelet count 1000/ mm3 hematocrit 39%, WBC 7300/mm3 and RBC 466 x 10(4)/mm3. Immune thrombocytopenic purpura (ITP) was diagnosed, and she was treated with 40 mg of methylprednisolone per day for 19 days. Her platelet count increased to 130,000/ mm3. Her left ovarian cyst was extirpated surgically, and the histological diagnosis was endometrial cyst. Danazol at 400 mg per day was therefore again administered. On the next day, she complained of gingival bleeding and purpura again, and her platelet count was 5000/mm3. We diagnosed this case as danazol induced thrombocytopenia.
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Case Reports Danazol Induced Thrombocytopenia 1997 Volume 182 Issue 3 Pages 249-252 Details Abstract A 34-year-old woman with a left ovarian cyst (clinically diagnosed as endometrial cyst) was treated with 400 mg of danazol per day. On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred. Her laboratory findings were as follows: platelet count 1000/mm3 hematocrit 39%, WBC 7300/mm3 and RBC 466 x 104/mm3. Immune thrombocytopenic purpura (ITP) was diagnosed, and she was treated with 40 mg of methylprednisolone per day for 19 days. Her platelet count increased to 130,000 mm3. Her left ovarian cyst was extirpated surgically, and the histological diagnosis was endometrial cyst. Danazol at 400 mg per day was therefore again administered. On the next day, she complained of gingival bleeding and purpura again, and her platelet count was 5000/mm3. We diagnosed this case as danazol induced thrombocytopenia. © 1997 Tohoku University Medical Press Favorites & Alerts Recently viewed articles - About this Journal The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology. - Submitted manuscripts will be screened for plagiarism with Similarity Check (https://www.crossref.org/services/similarity-check/). Announcements from publisher - Subscriptions Inland subscriptions should be sent to Tohoku University Medical Press, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JAPAN. Subscriptions from abroad should be addressed to MARUZEN CO., LTD., EXPORT DEPARTMENT, Postal address: P.O.Box 75, Shinagawa, Tokyo 140-8799, JAPAN. e-mail: [email protected]

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