Economic Evaluation of Oxaliplatin Hypersensitivity: A Retrospective Cohort Study

Economic Evaluation of Oxaliplatin Hypersensitivity: A Retrospective Cohort Study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 31 December 2025 V1 Latest version Share on Economic Evaluation of Oxaliplatin Hypersensitivity: A Retrospective Cohort Study Authors : Laura V. Carpio-Escalona 0000-0002-8741-6716 [email protected] , Federico Longo-Muñoz , Belén de la Hoz 0000-0002-5127-8702 , and David González-de-Olano 0000-0001-6653-4900 Authors Info & Affiliations https://doi.org/10.22541/au.176717720.08908656/v1 136 views 82 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: Oxaliplatin hypersensitivity reactions (OHRs) occur in approximately 25% of patients receiving chemotherapy for colorectal cancer. Appropriate allergy workup, including skin prick testing and drug provocation testing (DPT), may prevent unnecessary desensitization (DSni) or early therapeutic line switches (ETLS), both of which have cost and survival implications. This retrospective study aimed to evaluate the clinical and economic outcomes associated with different OHR management strategies, including DPT, DS, DSni, and ETLS, and compare them with patients without hypersensitivity reactions (non-OHR). Methods: A total of 268 patients with stage III to IV colorectal cancer treated between 2010 and 2022 were analyzed. Among them, 148 experienced OHRs and 120 did not. Within the OHR group, subcohorts included those undergoing DS (n=89), DSni (n=3), ETLS (n=21), and negative DPT (nDPT, n=35). Overall survival (OS) and direct medical costs were assessed. Survival was analyzed using Kaplan-Meier curves and log-rank tests. Costs included oncology- and allergy-related expenses. Results: The median OS for OHR patients with allergy work-up was 63.67 months, compared to 60.57 months for non-OHRs (p=0.109). Patients in the nDPT group had the longest OS (65.47 months) and the lowest cost (€134,768.00), while DSni patients had shorter OS (52.60 months) and higher cost (€135,408.00). ETLS was associated with the lowest OS (55.86 months) and higher per-patient cost (€148,950.00). DS enabled continuation of first-line therapy with a median OS of 57.8 months at a mean cost of €127,031.00. DPT resulted in savings of ~€4,588.00 per patient compared with DSni. Conclusions: Allergy workup with DPT is clinically safe and cost-effective, offering survival benefit and cost savings over unnecessary desensitization and ETLS. Desensitization, when indicated, may also represent a reasonable management approach. Prospective studies are needed to validate these findings. Supplementary Material File (articule_revisor - laura carpio_cl07nov2025_12dec_vfinal.docx) Download 212.95 KB File (figures for review.docx) Download 294.68 KB File (tables.docx) Download 23.00 KB Information & Authors Information Version history V1 Version 1 31 December 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords allergy treament challenge tests drug allergy personlized medicine quality-of-life Authors Affiliations Laura V. Carpio-Escalona 0000-0002-8741-6716 [email protected] Ramón y Cajal University Hospital IRYCIS View all articles by this author Federico Longo-Muñoz Ramón y Cajal University Hospital IRYCIS View all articles by this author Belén de la Hoz 0000-0002-5127-8702 Ramón y Cajal University Hospital IRYCIS View all articles by this author David González-de-Olano 0000-0001-6653-4900 Ramón y Cajal University Hospital IRYCIS View all articles by this author Metrics & Citations Metrics Article Usage 136 views 82 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Laura V. Carpio-Escalona, Federico Longo-Muñoz, Belén de la Hoz, et al. Economic Evaluation of Oxaliplatin Hypersensitivity: A Retrospective Cohort Study. Authorea . 31 December 2025. DOI: https://doi.org/10.22541/au.176717720.08908656/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 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