Efficiency of different biopsy methods of adenomyosis diagnosis, comparative analisis

С. А. Повзун, V. F. Bezhenar, Yuri V. Tsvelev, Д. Б. Фридман
In: Journal of obstetrics and women's diseases · 2005 · vol. 54(5S) , pp. 45 · doi:10.17816/jowd87373 · W3214337424
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This comparative analysis evaluated the efficiency of various low-invasive biopsy methods for definitively diagnosing adenomyosis through histological examination of myometrium samples.

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This study evaluated the diagnostic efficiency of various biopsy techniques for adenomyosis by performing in vitro simulations on hysterectomy specimens where pathology had already confirmed the condition. The researchers compared pinch, resection, transcervical puncture, and transabdominal puncture biopsies, noting that pinch and resection methods suffered from insufficient sample volume or thermal necrosis that hindered histological analysis. Transcervical puncture biopsy demonstrated superior sensitivity, particularly for deeper nodular lesions, while transabdominal approaches failed to assess invasion depth effectively. This paper is centrally about adenomyosis — specifically comparing the diagnostic accuracy and technical limitations of different minimally invasive biopsy methods for confirming the disease via myometrial sampling.

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Abstract

Introduction.Usage of low invasive methods in adenomyosis diagnosis helps to diagnose adenomyosis definitely by histological examination of myometrium samples.
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Abstract

Introduction.Usage of low invasive methods in adenomyosis diagnosis helps to diagnose adenomyosis definitely by histological examination of myometrium samples. Full Text Introduction.Usage of low invasive methods in adenomyosis diagnosis helps to diagnose adenomyosis definitely by histological examination of myometrium samples.

Material

and methods. Hysterectomy specimen (n=32), in 24 (75%) cases the adenomyosis was confirmed by pathologic examination. Imitation of transcervical and transabdominal puncture biopsy, pinch and resection biopsy in vitro were performed.

Results

- pinch biopsy is characterized by low volume of myometrium sample ~lmm3, unavailability to obtain deep located areas of myometrium, - resectobiopsy is characterized by unavailability to obtain deep located areas of myometrium, high side thermal necrosis, making 70% of preparation impossible for histological analysis. - Sensitivity of transcervical puncture biopsy for 5-nodular is 48%, 6-8 nodular - 83%, this method provides possibility to obtain deep located areas of myometrium; - transabdominal puncture biopsy gets tissue samples from external zones of myometrium, making impossible determine the depth of endometrial invasion. Sensitivity of transabdominal biopsy is 58% for 8-nodular biopsy. - 6-nodular transcervical biopsy - is the optimal method to obtain histological samples confirming adenomyosis. About the authors S. A. Povzun The D.O.Ott Research Institution of Obstetrics and Gynecology RAMS' Author for correspondence. Email: [email protected] Department of Pathological Anatomy Russian Federation, Saint PetersburgV. F. Bezhenar The D.O.Ott Research Institution of Obstetrics and Gynecology RAMS' Email: [email protected] Department of Pathological Anatomy Russian Federation, Saint PetersburgY. V. Tsvelev Medical-Military Academy Email: [email protected] Department of Obstetrics and Gynecology Russian Federation, Saint PetersburgD. B. Fridman The D.O.Ott Research Institution of Obstetrics and Gynecology RAMS'; Medical-Military Academy Email: [email protected] Department of Pathological Anatomy, Department of Obstetrics and Gynecology Russian Federation, Saint Petersburg; Saint Petersburg

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adenomyosis

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