Angiogenesis in ovarian clear cell carcinoma and its relation to endometriosis.

Deguchi M, M Deguchi, Masahiro Deguchi, Yoshinari Matsumoto, Matsumoto Y, Y Matsumoto, O Ishiko, Osamu Ishiko, Ishiko O, Shin Ogita, S Ogita, Ogita S
Oncology reports · 2000 · vol. 7(3) , pp. 651–4 · doi:10.3892/or.7.3.651 · PMID:10767384 · W2065481979
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This study investigated VEGF and PD-ECGF expression in ovarian clear cell carcinoma and found a significant correlation between VEGF expression and microvessel count, but no correlation with endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This study enrolled 25 patients with ovarian clear cell carcinoma and examined tumor expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF), correlating these measures with microvessel count (MVC). VEGF was strongly positive in 16 cases, weakly positive in 6, and negative in 3, while PD-ECGF was strongly positive in 11 cases, weakly positive in 6, and negative in 8. VEGF expression correlated significantly with MVC (p<0.01), but there were no correlations among complication by endometriosis, VEGF expression, PD-ECGF expression, and MVC. The paper is centrally about endometriosis’s role as a complication category in ovarian clear cell carcinoma angiogenesis, reporting that endometriosis complication did not relate to VEGF/PD-ECGF expression or MVC.

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Abstract

Twenty-five patients with ovarian clear cell carcinoma (CC-Ca) were enrolled in this study, and tumor cell expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) was investigated, and correlated with the microvessel count (MVC) and the impact of complication endometriosis. Expression of VEGF was strongly positive in 16 cases, weakly positive in 6 cases, and negative in 3 cases. Expression of PD-ECGF was strongly positive in 11 cases, weakly positive in 6 cases, and negative in 8 cases. VEGF expression and the MVC were significantly correlated (p<0.01), and there were no correlations among complication by endometriosis, expression of VEGF, expression of PD-ECGF, and MVC.
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Print ISSN: 1021-335X Online ISSN: 1791-2431 International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Article - Authors: - Pages: 651-655|Published online on: May 1, 2000https://doi.org/10.3892/or.7.3.651 - Expand metrics + Twenty-five patients with ovarian clear cell carcinoma (CC-Ca) were enrolled in this study, and tumor cell expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) was investigated, and correlated with the microvessel count (MVC) and the impact of complication endometriosis. Expression of VEGF was strongly positive in 16 cases, weakly positive in 6 cases, and negative in 3 cases. Expression of PD-ECGF was strongly positive in 11 cases, weakly positive in 6 cases, and negative in 8 cases. VEGF expression and the MVC were significantly correlated (p<0.01), and there were no correlations among complication by endometriosis, expression of VEGF, expression of PD-ECGF, and MVC. Copy and paste a formatted citation Spandidos Publications style Deguchi M, Matsumoto Y, Ishiko O and Ogita S: Angiogenesis in ovarian clear cell carcinoma and its relation to endometriosis.. Oncol Rep 7: 651-655, 2000. APA Deguchi, M., Matsumoto, Y., Ishiko, O., & Ogita, S. (2000). Angiogenesis in ovarian clear cell carcinoma and its relation to endometriosis.. Oncology Reports, 7, 651-655. https://doi.org/10.3892/or.7.3.651 MLA Deguchi, M., Matsumoto, Y., Ishiko, O., Ogita, S."Angiogenesis in ovarian clear cell carcinoma and its relation to endometriosis.". Oncology Reports 7.3 (2000): 651-655. Chicago Deguchi, M., Matsumoto, Y., Ishiko, O., Ogita, S."Angiogenesis in ovarian clear cell carcinoma and its relation to endometriosis.". Oncology Reports 7, no. 3 (2000): 651-655. https://doi.org/10.3892/or.7.3.651

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Endometriosis Microcirculation Neovascularization, Pathologic Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adult Aged Endometriosis Endothelial Growth Factors Endothelial Growth Factors Female Humans Lymphokines Lymphokines Microcirculation Middle Aged

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