In-vivo parcellation of human subcortex by multi-modal MRI

In-vivo parcellation of human subcortex by multi-modal MRI | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article In-vivo parcellation of human subcortex by multi-modal MRI Tonima Ali, Jinglei Lv, Mustafa Kassem, Arkiev D'Souza, Claire O’Callaghan, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4203104/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract Human subcortical grey matter (SGM) structures are crucial hubs for processing, transmitting and modulating brain-wide signals. However, in-vivo characterisation of subnuclei within the SGM structures remains limited, restricting our knowledge of their roles in brain function and in disorders. To address this gap, we introduce the Sydney Subcortical Gray Matter (SydSGM) parcellation— based on a novel data-driven approach using multiple MRI contrasts to assess myelination, directionality of white matter fibres, and diffusion micro-environment. Fifty-four distinct parcels were identified across caudate, putamen, globus pallidus, nucleus accumbens, and thalamus based on the coherent representation of these attributes, which demonstrated remarkable concordance with histology-based delineations. The SydSGM parcellation now facilitates detailed structural connectivity analysis at the subnuclei scale. It can be adopted as a standalone atlas or incorporated into existing brain atlases. We demonstrate SydSGM parcellation’s advantage by revealing declined structural connectivity of highly resolved SGM subnuclei in patients with early Parkinson’s disease. Biological sciences/Neuroscience/Computational neuroscience Biological sciences/Neuroscience/Cognitive neuroscience Full Text Additional Declarations There is NO Competing Interest. Supplementary Files SupplNatureMethods.pdf Supplementary Discussion Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4203104","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":286697243,"identity":"54114bfd-f61c-41d8-be1e-e9d4d7cb8567","order_by":0,"name":"Tonima 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