Probiotic lactic acid bacteria induce regulatory functions in γδ T cells

Abstract While the modulatory effects of probiotic LAB on conventional T cells are well documented, its effects on unconventional T cells, including gamma-delta (γδ) T cells, have not yet been fully characterized. In this study, we show that probiotic LAB has the capacity to generate regulatory γδ T cells. Probiotic LAB stimulation significantly increased interleukin (IL)-10, but not IFN-γ or IL-17A, in γδ T cells compared to stimulation with methicillin-resistant Staphylococcus aureus (MRSA). This regulatory function subsequently attenuated IL-8 production in intestinal epithelial cells. Thus, probiotic LAB can induce regulatory functions in γδ T cells, which may contribute to the maintenance of intestinal health. Competing Interest Statement The authors have declared no competing interest.