Clinical values of combined detection of HE4 and LPA in diagnosis of endometrial carcinoma

Objective To investigate the diagnostic value of combined detection of human epididymis proteins4(HE4)and lysophosphatidic acid LPA for endometrial carcinoma.Methods Enzyme linked immunosorbent assay and electrochemiluminescence were used for the detection of serum HE4and plasma LPA in healthy subjects and three patient groups,including endometrial cancer,endometriosis uterine and dysfunctional uterine bleeding.The levels and positive rates of serum HE4and plasma LPA were compared between the four groups.The diagnostic performance of HE4,LPA and combined detection in endometrial cancer were analyzed.Results The levels of HE4and LPA in endometrial cancer patients were obviously higher than the other three groups(P0.05).The diagnostic sensitivities of HE4and LPA in diagnosis of endometrial cancer were 48.58%and 68.96%respectively,and the specificities were 95.74% and 87.23% respectively.The specificity of combined detection of HE4and LPA was87.23%,and the sensitivity was 75.86%,which was higher than individual detection(P0.05).Conclusion The diagnostic value of combined detection of serum HE4and LPA could be higher than individual detection for the diagnosis of endometrial cancer.