Evaluation of a new dengue 3 controlled human infection model for use in the evaluation of candidate dengue vaccines
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Abstract
All four serotypes of dengue virus (DENV) cause the full spectrum of disease. Therefore, vaccines must protect against all serotypes. To evaluate candidate vaccines, a human challenge model of dengue serotype 3 (rDEN30Δ30) was developed. All challenge virus recipients safely met the primary endpoint of viremia and secondary endpoints of rash and seroconversion to DENV-3.
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- last seen: 2026-05-19T01:45:01.086888+00:00