Highly Sensitive Silver/Tin Selenide/Graphene Multilayer SPR Sensor for Hemoglobin and Glucose Levels Monitoring in Biological Fluids

Highly Sensitive Silver/Tin Selenide/Graphene Multilayer SPR Sensor for Hemoglobin and Glucose Levels Monitoring in Biological Fluids | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Highly Sensitive Silver/Tin Selenide/Graphene Multilayer SPR Sensor for Hemoglobin and Glucose Levels Monitoring in Biological Fluids Ahmad M. Alsaad, M. Al-Hmoud, M. W. Marashdeh, Elen Tolstik, Milad Houshmand, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4566105/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 19 Jul, 2024 Read the published version in Plasmonics → Version 1 posted 9 You are reading this latest preprint version Abstract This work presents the simulation of a novel surface plasmon resonance (SPR) biosensor composed of silver/tin-selenide/graphene. The designed sensor aims to detect biological constituents in various chemical and biological solutions. While simulation packages based on finite element methods (FEM) are typically utilized in engineering and physics for structural and fluid dynamics analyses, their application in medical diagnostics is less common. In this study, we employed a simple FEM simulation method for medical diagnostics. The functionality of the proposed FEM-based simulated biosensor is examined by testing it on hemoglobin and glucose samples of a diabetic person. In the blood samples analyzed, a 6.1025 g/l increase in hemoglobin (HB) level corresponded to a 0.001 refractive index unit (RIU) increment. The SPR sensor design presented in this work demonstrated a novel capability to detect such minute changes using a simple and cost-effective setup, achieving an angular sensitivity of 158 deg/RIU. Additionally, the SPR sensor was employed for detecting glucose concentrations in urine samples, offering a potential indicator for diabetes diagnosis. The novelty of this SPR sensor lies in its simple schematic design, enabling precise detection of both hemoglobin and glucose levels. SPR biosensors Index of refraction Tin Selenide (SnSe) Hemoglobin Level Glucose Level Graphene Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 19 Jul, 2024 Read the published version in Plasmonics → Version 1 posted Editorial decision: Revision requested 29 Jun, 2024 Reviews received at journal 28 Jun, 2024 Reviews received at journal 22 Jun, 2024 Reviewers agreed at journal 19 Jun, 2024 Reviewers agreed at journal 19 Jun, 2024 Reviewers invited by journal 19 Jun, 2024 Editor assigned by journal 12 Jun, 2024 Submission checks completed at journal 12 Jun, 2024 First submitted to journal 11 Jun, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4566105","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":318362232,"identity":"09e55ce3-2ed6-4747-9b44-254645cef85e","order_by":0,"name":"Ahmad M. 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