Microarray Analysis Shows Important ID3 – BMP9 Driven Gene Signatures

Bone morphogenetic protein 9 (BMP9) is a cytokine belonging to the transforming growth – beta (TGF-β) family mainly known for its role in regulating vascular function, specifically keeping blood vessels stable and preventing unwarranted growth. It has been previously demonstrated to be involved in hereditary hemorrhagic telangiectasia (HHT) and vascular remodeling acting via HHT target genes. Inhibitor of Differentiation/DNA – Binding 3 (ID3) has been known to be a significant mediator for stages of cell differentiation within the context of BMP9 signaling in HHT development; however, the roles of ID3 and its targets within the HHT pathways are still limited. This brief report highlights significant ID3 targeted - BMP9 gene signatures and networks that may play a key role in the modifications of HHT.