Construction of an Evaluation Model for the Protective Efficacy of Ovine Brucellosis Vaccines

Construction of an Evaluation Model for the Protective Efficacy of Ovine Brucellosis Vaccines | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Construction of an Evaluation Model for the Protective Efficacy of Ovine Brucellosis Vaccines Shihua Niu, Yong Meng, Churiga Man, Weiwei Wu, Wenxin Zheng, Dongling Wu, and 15 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7705539/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract This study developed a comprehensive model for evaluating sheep brucellosis vaccine efficacy by integrating bacteriological, immunological, and pathological indicators.Thirty-three healthy Xinjiang fine-wool sheep were challenged via conjunctival instillation with Brucella melitensis strain M28, and paired lymph nodes, spleen, and serum were collected post-infection. Principal Component Analysis (PCA) identified three principal components (81.935% variance), whose comprehensive score (F) strongly correlated with average bacterial load ( P < 0.01, AUC = 0.905); key indicators included left submandibular, left prescapular, and left inguinal lymph node bacterial loads, and cELISA antibody titers. An optimized stepwise regression model retained 9 indicators (SAT, cELISA, cELISA (BS), IL-12, IL-17, left parotid lymph node bacterial loads, left submandibular lymph node bacterial loads, left parotid lymph node gross anatomical scores, right parotid lymph node gross anatomical scores). This model (R) demonstrated superior predictive accuracy (AUC = 0.974, Rho = 0.864 vs. PCA's 0.905 and 0.768) and revealed IL-17 positively and IL-12 negatively regulated bacterial load. This study presents the first comprehensive system for sheep brucellosis vaccine efficacy, offering robust technical support for eradication efforts. Brucella sheep Protective immunity PCA Stepwise regression analysis ROC analysis Full Text Additional Declarations No competing interests reported. Supplementary Files Additionalfile.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7705539","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":536928637,"identity":"61fba16c-f259-49ba-9690-7e33ecac30ae","order_by":0,"name":"Shihua Niu","email":"","orcid":"","institution":"Hainan University","correspondingAuthor":false,"prefix":"","firstName":"Shihua","middleName":"","lastName":"Niu","suffix":""},{"id":536928638,"identity":"95e5d427-740b-497a-b35d-d603449c8b0b","order_by":1,"name":"Yong Meng","email":"","orcid":"","institution":"Hainan 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Vaccines","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Brucella, sheep, Protective immunity, PCA, Stepwise regression analysis, ROC analysis","lastPublishedDoi":"10.21203/rs.3.rs-7705539/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7705539/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThis study developed a comprehensive model for evaluating sheep brucellosis vaccine efficacy by integrating bacteriological, immunological, and pathological indicators.Thirty-three healthy Xinjiang fine-wool sheep were challenged \u003cem\u003evia\u003c/em\u003e conjunctival instillation with \u003cem\u003eBrucella melitensis\u003c/em\u003e strain M28, and paired lymph nodes, spleen, and serum were collected post-infection. Principal Component Analysis (PCA) identified three principal components (81.935% variance), whose comprehensive score (F) strongly correlated with average bacterial load (\u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.01, AUC\u0026thinsp;=\u0026thinsp;0.905); key indicators included left submandibular, left prescapular, and left inguinal lymph node bacterial loads, and cELISA antibody titers. An optimized stepwise regression model retained 9 indicators (SAT, cELISA, cELISA (BS), IL-12, IL-17, left parotid lymph node bacterial loads, left submandibular lymph node bacterial loads, left parotid lymph node gross anatomical scores, right parotid lymph node gross anatomical scores). This model (R) demonstrated superior predictive accuracy (AUC\u0026thinsp;=\u0026thinsp;0.974, Rho\u0026thinsp;=\u0026thinsp;0.864 vs. PCA's 0.905 and 0.768) and revealed IL-17 positively and IL-12 negatively regulated bacterial load. This study presents the first comprehensive system for sheep brucellosis vaccine efficacy, offering robust technical support for eradication efforts.\u003c/p\u003e","manuscriptTitle":"Construction of an Evaluation Model for the Protective Efficacy of Ovine Brucellosis Vaccines","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-10-30 16:01:19","doi":"10.21203/rs.3.rs-7705539/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"6510bc4b-cdb8-4b86-8f27-1d7c015f5fd5","owner":[],"postedDate":"October 30th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-11-08T05:08:11+00:00","versionOfRecord":[],"versionCreatedAt":"2025-10-30 16:01:19","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7705539","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7705539","identity":"rs-7705539","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}