Estimation of impurity profiles in drugs and related materials. Part 11 — the role of chromatographic and spectroscopic methods in the estimation of side-reactions in drug syntheses

S. Go ̈ro ̈g, Gábor Balogh, A. Csehi, E ́. Csize ́r, M. Gazdag, Zs. Halmos, B. Hegedu ̈s, B. Here ́nyi, P. Horva´th, Anna Laukó
In: Journal of Pharmaceutical and Biomedical Analysis · 1993 · vol. 11(11-12) , pp. 1219–1226 · doi:10.1016/0731-7085(93)80107-c · PMID:8123737 · W2037794346
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This paper discusses the use of chromatographic and spectroscopic methods to identify and quantify side-products formed during drug synthesis.

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Abstract

Impurities in drugs are classified on the basis of the types of side-reactions in drug syntheses resulting in their formation. This is shown by summarizing the authors' earlier results in the field of impurity profiling of 19-nor-steroids, ethynodiol diacetate, mazipredone, pipecuronium bromide, flumecinol, enalapril, pyridinol carbamate, phenylbutazone, thymotrinan and some new results related to danazol and famotidine.

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