Evaluating the Impact of Dienogest on Quality of Life in Turkish Patients with Endometriosis: A Clinical Study

Tevfik Berk Bıldacı, Y Atmaca, Can Ata, Ufuk Atlıhan, Hüseyin Aytuğ Avşar, Selçuk Erkılınç
In: Acıbadem Üniversitesi Sağlık Bilimleri Dergisi · 2025 · vol. 16(4) , pp. 534–539 · doi:10.31067/acusaglik.1668799 · W4414187977
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Dienogest treatment significantly improved overall quality of life and specific domains including pain, self-image, and emotional well-being in Turkish patients with endometriosis.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-09 · read from full text ⓘ

This clinical study evaluated the impact of dienogest on quality of life in Turkish patients with endometriosis, using a quality-of-life assessment administered before and after treatment. The key finding reported was that treatment with dienogest was associated with measurable changes in patients’ quality-of-life scores. A major limitation is that the details needed to fully interpret the strength of causal inference (e.g., sample size, duration of follow-up, and study design specifics) are not provided in the excerpted text available here. This paper is centrally about endometriosis — specifically, it assesses how dienogest affects quality of life in Turkish patients.

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Abstract

Purpose This study aimed to evaluate the effectiveness of dienogest in alleviating the negative effects associated with endometriosis in Turkish patients. The impact of the treatment on health-related quality of life (HRQoL) was assessed using the validated Turkish version of the Endometriosis Health Profile-30 (EHP-30) questionnaire. Methods A total of 119 patients with a confirmed diagnosis of endometrioma characterized by a unilocular cyst with homogeneous ground-glass echogenicity were included in this study, conducted at a tertiary care center. All participants were prescribed or already have been prescribed a continuous regimen of 2 mg/day dienogest for symptom control. Each patient completed the core section of the EHP-30 questionnaire twice: before treatment initiation and after a defined treatment period. Results A significant improvement was observed in total EHP-30 scores (from 96.92 to 52.03, p < .001). Notable improvements were also found in the pain (p < .001), self-image (p < .001), and emotional well-being (p < .001) subdomains. Changes in EHP-30 scores were not found to be significantly correlated with treatment duration, reduction in endometrioma size, or changes in CA125 levels. Conclusion Dienogest significantly improves quality of life even with short-term use and stands out as an effective treatment option for endometriosis.
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- 1. Chapron C, Marcellin L, Borghese B, et al. Rethinking mechanisms, diagnosis and management of endometriosis. Nat Rev Endocrinol. 2019;15(11):666-82. Epub 20190905. doi: 10.1038/s41574-019- 0245-z. PubMed PMID: 31488888. - 2. Vitale SG, Capriglione S, Peterlunger I, et al. The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner. Oxid Med Cell Longev. 2018;2018:7924021. Epub 20180321. doi: 10.1155/2018/7924021. PubMed PMID: 29743986; PubMed Central PMCID: PMC5883985. - 3. Parasar P, Ozcan P, Terry KL. Endometriosis: Epidemiology, Diagnosis and Clinical Management. Curr Obstet Gynecol Rep. 2017;6(1):34-41. Epub 20170127. doi: 10.1007/s13669-017-0187-1. PubMed PMID: 29276652; PubMed Central PMCID: PMC5737931. - 4. Koninckx PR, Fernandes R, Ussia A, et al. Pathogenesis Based Diagnosis and Treatment of Endometriosis. Front Endocrinol (Lausanne). 2021;12:745548. Epub 20211125. doi: 10.3389/ fendo.2021.745548. PubMed PMID: 34899597; PubMed Central PMCID: PMC8656967. - 5. Laganà AS, La Rosa VL, Rapisarda AMC, et al. Anxiety and depression in patients with endometriosis: impact and management challenges. Int J Womens Health. 2017;9:323-30. Epub 20170516. doi: 10.2147/ ijwh.S119729. PubMed PMID: 28553145; PubMed Central PMCID: PMC5440042. - 6. Jia SZ, Leng JH, Shi JH, et al. Health-related quality of life in women with endometriosis: a systematic review. J Ovarian Res. 2012;5(1):29. Epub 20121018. doi: 10.1186/1757-2215-5-29. PubMed PMID: 23078813; PubMed Central PMCID: PMC3507705. - 7. Grundström H, Gerdle B, Alehagen S, et al. Reduced pain thresholds and signs of sensitization in women with persistent pelvic pain and suspected endometriosis. Acta Obstet Gynecol Scand. 2019;98(3):327-36. Epub 20181230. doi: 10.1111/aogs.13508. PubMed PMID: 30472739. - 8. Marques A, Bahamondes L, Aldrighi JM, et al. Quality of life in Brazilian women with endometriosis assessed through a medical outcome questionnaire. J Reprod Med. 2004;49(2):115-20. PubMed PMID: 15018440. Details Primary Language English Subjects Obstetrics and Gynaecology Journal Section Research Article Authors Can Ata 0000-0002-0841-0480 Türkiye Ufuk Atlıhan 0000-0002-2109-1373 Türkiye Selçuk Erkılınç 0000-0002-6512-9070 Türkiye Early Pub Date September 15, 2025 Publication Date October 1, 2025 Submission Date April 1, 2025 Acceptance Date June 24, 2025 Published in Issue Year 2025 Volume: 16 Number: 4

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EHP-30

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endometriosisendometrioma

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