The aftermath of Post COVID-19 Condition in Italy and the United States: an ecological comparison

The aftermath of Post COVID-19 Condition in Italy and the United States: an ecological comparison | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article The aftermath of Post COVID-19 Condition in Italy and the United States: an ecological comparison Jacopo Garlasco, Mario Nurchis, Gian Mario Raspolini, Aurora Heidar Alizadeh, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4306384/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Post COVID-19 Condition (PCC) is a clinical syndrome following COVID-19 disease. PCC symptoms in adults entail significant productivity loss and reduced quality of life. This study aimed at estimating the epidemiological and economic burden of PCC among the working-age population of Italy and the US. This ecological analysis was conducted on data from January 2020 to April 2023, regarding population aged 18-64. PCC incidence was retrieved for the US, while for Italy it was estimated from COVID-19 cases. Prevalence of factors associated with PCC and parameters to calculate temporary productivity losses (TPL) were retrieved. An estimated Incidence Rate Ratio (eIRR) of PCC incidence in Italy and the US was calculated. TPL for reduced earnings and total Quality-Adjusted Life Years (QALYs) lost were also estimated. The ecological eIRR Italy/US was 0.842 [95%CI: 0.672–1.015], suggesting that, holding COVID-19 cases constant, 15.8% fewer PCC cases have occurred in Italy compared to the US. Overall PCC cases were found to be roughly 12.0 [95%CI: 9.9–14.1] million in the US, with 1.9 [95%CI: 1.6–2.3] million QALYs lost, and around 2.4 [95%CI: 1.8–3.0] million in Italy, with 0.4 [95%CI: 0.3–0.5] million QALYs lost. Up to April 2023, the TPL was estimated to be €4.5 [95%CI: 3.5–6.1] billion in Italy and $41.5 [95%CI: 34.3–48.7] billion in the US. PCC has had a significant epidemiological and economic impact on the working-age population. The findings from this study may be of use for health planning and policy regarding PCC in working-age adults. Health sciences/Medical research Scientific community and society/Social sciences/Economics Post COVID-19 condition quality-adjusted life years loss productivity loss health policy epidemiological burden Full Text Additional Declarations There is NO Competing Interest. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4306384","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":294537228,"identity":"7d870ff9-575f-4c61-912d-ca0fbc15428e","order_by":0,"name":"Jacopo 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PCC symptoms in adults entail significant productivity loss and reduced quality of life. This study aimed at estimating the epidemiological and economic burden of PCC among the working-age population of Italy and the US. This ecological analysis was conducted on data from January 2020 to April 2023, regarding population aged 18-64. PCC incidence was retrieved for the US, while for Italy it was estimated from COVID-19 cases. Prevalence of factors associated with PCC and parameters to calculate temporary productivity losses (TPL) were retrieved. An estimated Incidence Rate Ratio (eIRR) of PCC incidence in Italy and the US was calculated. TPL for reduced earnings and total Quality-Adjusted Life Years (QALYs) lost were also estimated.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe ecological eIRR Italy/US was 0.842 [95%CI: 0.672–1.015], suggesting that, holding COVID-19 cases constant, 15.8% fewer PCC cases have occurred in Italy compared to the US. Overall PCC cases were found to be roughly 12.0 [95%CI: 9.9–14.1] million in the US, with 1.9 [95%CI: 1.6–2.3] million QALYs lost, and around 2.4 [95%CI: 1.8–3.0] million in Italy, with 0.4 [95%CI: 0.3–0.5] million QALYs lost. Up to April 2023, the TPL was estimated to be €4.5 [95%CI: 3.5–6.1] billion in Italy and $41.5 [95%CI: 34.3–48.7] billion in the US.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003ePCC has had a significant epidemiological and economic impact on the working-age population. 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