Mental Disorders in Multiple Endocrine Neoplasia Type 1

Menin, the product of Multiple Endocrine Neoplasia type 1 (MEN1) gene, is a scaffold protein, the lack of which generates the development of a tumor syndrome primarily affecting the endocrine organs. Although it is classified as an oncosuppressor, menin is a ubiquitous protein whose expression is also abundant in non- endocrine tissues such as the central nervous system, where knowledge of menin's role still remains limited. In this article, we have tried to draw attention to an underestimated clinical aspect of MEN1 syndrome, i.e., the psychological/psychiatric manifestations, in which menin deficiency could have an important function. Our aim is to highlight that a multidisciplinary team caring for a MEN1 patient throughout his or her life should include professionals such as psychologists and psychiatrists, in order to better manage any mental illness associated with the syndrome and to further improve the patient's quality of life.