Effect of tranexamic acid solution in warm, cold, and room temperature irrigation fluid on complications during and after TURP surgery: a double-blind, randomized clinical trial

Effect of tranexamic acid solution in warm, cold, and room temperature irrigation fluid on complications during and after TURP surgery: a double-blind, randomized clinical trial | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Effect of tranexamic acid solution in warm, cold, and room temperature irrigation fluid on complications during and after TURP surgery: a double-blind, randomized clinical trial masoomeh salehi, behzad imani, shirdel zandi, hamed haghiabi, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4813561/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 18 Jan, 2025 Read the published version in African Journal of Urology → Version 1 posted 4 You are reading this latest preprint version Abstract Background and purpose: Transurethral resection of the prostate (TURP) is a surgical technique commonly used for benign prostatic hyperplasia. The most significant complications of this surgery are bleeding intraoperatively and shivering postoperatively. In this study, we aimed to investigate the effect of tranexamic acid (TXA) solution in warm, cold, and room-temperature irrigation fluid on these complications during and after TURP surgery. Materials and Methods: This study was a double-blind clinical trial conducted in Iran; 100 candidates for TURP surgery were selected using the Convenience sampling method and based on the intraoperative irrigation method: intervention group A (TXA compound solution in cold irrigation fluid), intervention group B (composition of TXA dissolved in room temperature irrigation fluid), intervention group C (TXA compound solution in cold irrigation fluid) and group control (routine irrigation). Intraoperative bleeding was measured with a photometer, hemoglobin was measured with a blood cell counter (Cell-Dyn3200), and post-operative shivering was measured using the Crossley and Mahajan scale. Findings: The amount of postoperative bleeding in the TXA solution in the cold irrigation fluid group was significantly lower than in the other groups. Post-operative shivering was significantly lower in the TXA solution group in warm irrigation fluid and the highest in the cold group. The data was analyzed using SPSS version 16. Conclusion: The results of this study showed that the composition of TXA in the cold irrigation solution potentially reduces intraoperative bleeding, but the amount of shivering postoperatively is more significant than in the warm solution and at room temperature. Tranexamic acid Irrigation Fluid Shivering Bleeding TURP Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 18 Jan, 2025 Read the published version in African Journal of Urology → Version 1 posted Editorial decision: Revision requested 06 Aug, 2024 Editor assigned by journal 01 Aug, 2024 Submission checks completed at journal 01 Aug, 2024 First submitted to journal 27 Jul, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4813561","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":336900280,"identity":"61ad8176-1e10-4b7d-8c2f-852d4bf88764","order_by":0,"name":"masoomeh salehi","email":"","orcid":"","institution":"Hamadan University of Medical Sciences","correspondingAuthor":false,"prefix":"","firstName":"masoomeh","middleName":"","lastName":"salehi","suffix":""},{"id":336900282,"identity":"25a8ea70-252a-41f1-92fe-e391b290d5b8","order_by":1,"name":"behzad 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randomized clinical trial","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"african-journal-of-urology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"afju","sideBox":"Learn more about [African Journal of Urology](http://link.springer.com/journal/12293)","snPcode":"12301","submissionUrl":"https://submission.springernature.com/new-submission/12301/3","title":"African Journal of Urology","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Tranexamic acid, Irrigation Fluid, Shivering, Bleeding, TURP","lastPublishedDoi":"10.21203/rs.3.rs-4813561/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4813561/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground and purpose: Transurethral resection of the prostate (TURP) is a surgical technique commonly used for benign prostatic hyperplasia. The most significant complications of this surgery are bleeding intraoperatively and shivering postoperatively. In this study, we aimed to investigate the effect of tranexamic acid (TXA) solution in warm, cold, and room-temperature irrigation fluid on these complications during and after TURP surgery.\u003c/p\u003e\n\u003cp\u003eMaterials and Methods: This study was a double-blind clinical trial conducted in Iran; 100 candidates for TURP surgery were selected using the Convenience sampling method and based on the intraoperative irrigation method: intervention group A (TXA compound solution in cold irrigation fluid), intervention group B (composition of TXA dissolved in room temperature irrigation fluid), intervention group C (TXA compound solution in cold irrigation fluid) and group control (routine irrigation). Intraoperative bleeding was measured with a photometer, hemoglobin was measured with a blood cell counter (Cell-Dyn3200), and post-operative shivering was measured using the Crossley and Mahajan scale.\u003c/p\u003e\n\u003cp\u003eFindings: The amount of postoperative bleeding in the TXA solution in the cold irrigation fluid group was significantly lower than in the other groups. Post-operative shivering was significantly lower in the TXA solution group in warm irrigation fluid and the highest in the cold group. The data was analyzed using SPSS version 16.\u003c/p\u003e\n\u003cp\u003eConclusion: The results of this study showed that the composition of TXA in the cold irrigation solution potentially reduces intraoperative bleeding, but the amount of shivering postoperatively is more significant than in the warm solution and at room temperature.\u003c/p\u003e","manuscriptTitle":"Effect of tranexamic acid solution in warm, cold, and room temperature irrigation fluid on complications during and after TURP surgery: a double-blind, randomized clinical trial","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-08-28 19:50:00","doi":"10.21203/rs.3.rs-4813561/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2024-08-06T22:40:30+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-08-02T01:00:35+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-08-02T00:59:29+00:00","index":"","fulltext":""},{"type":"submitted","content":"African Journal of Urology","date":"2024-07-27T14:35:57+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"african-journal-of-urology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"afju","sideBox":"Learn more about [African Journal of Urology](http://link.springer.com/journal/12293)","snPcode":"12301","submissionUrl":"https://submission.springernature.com/new-submission/12301/3","title":"African Journal of Urology","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"6146a10f-c9ed-45b2-937e-c63ee59bd3e7","owner":[],"postedDate":"August 28th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2025-01-20T16:01:48+00:00","versionOfRecord":{"articleIdentity":"rs-4813561","link":"https://doi.org/10.1186/s12301-025-00476-z","journal":{"identity":"african-journal-of-urology","isVorOnly":false,"title":"African Journal of Urology"},"publishedOn":"2025-01-18 15:57:26","publishedOnDateReadable":"January 18th, 2025"},"versionCreatedAt":"2024-08-28 19:50:00","video":"","vorDoi":"10.1186/s12301-025-00476-z","vorDoiUrl":"https://doi.org/10.1186/s12301-025-00476-z","workflowStages":[]},"version":"v1","identity":"rs-4813561","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4813561","identity":"rs-4813561","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}