Investigation on the relative association of CD44 and fibronectin expression with endometriosis

Objective:To study the expression of CD44s and fibronectin in endometriosis.Methods:Expression of CD44s and fibronectin were evaluated by immunohistochemistry method in entopic from 22 patients and in ectopic from 45 patients with endometriosis and the endometrial tissues of 20 non-endometriosis.Results:CD44s is restricted to epithelial cells;fibronectin is restricted to stroma,their expression remained constants thoughout the menstrual cycle.Decreased expression of CD44s and fibronectin in epithelial and stroma in endometriosis was found in eutopic endometrium(P0.05) and ectopic endometrium(P0.05) as compared with endometrium in controls.Conclusion:In patients with endometriosis CD44s and fibronectin expression changed significantly from eutopic to ectopic endometrium which maybe related to the development of endometriosis and infertility.