Controlled ovarian hyperstimulation and intrauterine insemination for infertility associated with endometriosis: a retrospective analysis

E N Tavmergen Göker, Göker EN, H T Ozçakir, Ozçakir HT, Terek MC, M C Terek, R. Levi, Levi R, Adakan S, S Adakan, E. Tavmergen, Tavmergen E
Archives of gynecology and obstetrics · 2002 · doi:10.1007/pl00007492 · PMID:11998959
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Controlled ovarian hyperstimulation and intrauterine insemination yielded similar pregnancy rates across endometriosis, male factor, tubal factor, and other infertility groups.

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This retrospective analysis evaluated controlled ovarian hyperstimulation with intrauterine insemination in 260 patients with infertility attributed to endometriosis (n=56), male factor (n=38), tubal factor (n=26), or other causes including unexplained infertility, ovulation disorders, and cervical factor (n=140). The study compared clinical pregnancy rates per patient across groups and analyzed hormone levels, endometrial thickness, and number of follicles, and it further compared endometriosis outcomes by stage (minimal to mild versus moderate to severe). Clinical pregnancy rates per patient were similar across the main groups, and within endometriosis subgroups pregnancy rates did not differ significantly. The paper’s main limitation is its retrospective design, with no prospective control of confounders, though it concludes that endometriosis stage did not affect pregnancy outcomes with the treatment used. This paper is centrally about endometriosis — it specifically assesses infertility treatment efficacy (controlled ovarian hyperstimulation and intrauterine insemination) across endometriosis stages.

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Abstract

OBJECTIVE: To evaluate the efficacy of controlled ovarian hyperstimulation and intrauterine insemination for infertility associated with endometriosis. MATERIAL AND METHODS: A retrospective analysis of 260 patients with the only diagnosis of endometriosis, or male factor, or tubal factor, or unexplained infertility were performed: a total of 56 patients with different stages of endometriosis, a control group consisting of 38 patients with male factor infertility, a group of 26 patients with tubal factor infertility and a group of 140 patients with others (unexplained infertility, ovulation disorders, cervical factor). Pregnancy rate, hormone levels, endometrial thickness and number of follicles were analyzed. RESULTS: Clinical pregnancy rates per patient were similar between endometriosis, male factor, tubal factor, and others including unexplained infertility, ovulation disorders and cervical factor groups (10.7%, 5.4%, 11.5%, 17.9%, respectively; p>0.05). Clinical pregnancy rates per patient were not effected between the 2 subgroups of endometriosis as minimal to mild and moderate to severe [5.1% (2/39) versus 23.5% (4/17), p=0.19]. CONCLUSION: Endometriosis did not affect the clinical pregnancy rate per patient compared to the other infertility factors. Endometriosis of various stages have no effect on the success of controlled ovarian hyperstimulation combined with intrauterine insemination.
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Abstract

Objective To evaluate the efficacy of controlled ovarian hyperstimulation and intrauterine insemination for infertility associated with endometriosis.

Material and methods

A retrospective analysis of 260 patients with the only diagnosis of endometriosis, or male factor, or tubal factor, or unexplained infertility were performed: a total of 56 patients with different stages of endometriosis, a control group consisting of 38 patients with male factor infertility, a group of 26 patients with tubal factor infertility and a group of 140 patients with others (unexplained infertility, ovulation disorders, cervical factor). Pregnancy rate, hormone levels, endometrial thickness and number of follicles were analyzed.

Results

Clinical pregnancy rates per patient were similar between endometriosis, male factor, tubal factor, and others including unexplained infertility, ovulation disorders and cervical factor groups (10.7%, 5.4%, 11.5%, 17.9%, respectively; p>0.05). Clinical pregnancy rates per patient were not effected between the 2 subgroups of endometriosis as minimal to mild and moderate to severe [5.1% (2/39) versus 23.5% (4/17), p=0.19].

Conclusion

Endometriosis did not affect the clinical pregnancy rate per patient compared to the other infertility factors. Endometriosis of various stages have no effect on the success of controlled ovarian hyperstimulation combined with intrauterine insemination. Similar content being viewed by others Author information Authors and Affiliations Additional information Received: 8 December 2000 / Accepted: 19 February 2001 Rights and permissions About this article Cite this article Tavmergen Göker, E., Özçakir, H., Terek, M. et al. Controlled ovarian hyperstimulation and intrauterine insemination for infertility associated with endometriosis: a retrospective analysis. Arch Gynecol Obstet 266, 21–24 (2002). https://doi.org/10.1007/PL00007492 Issue date: DOI: https://doi.org/10.1007/PL00007492

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Infertility, Female Insemination, Artificial, Homologous Ovulation Induction Adult Chorionic Gonadotropin Chorionic Gonadotropin Endometriosis Endometriosis Endometrium Endometrium Fallopian Tube Diseases Fallopian Tube Diseases Female Humans Infertility, Female Infertility, Male Infertility, Male Male

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