Serial Kasus : Presentasi Klinis dan Tata Laksana Nodul Endometriosis Subkutan

In: Jurnal Kedokteran Meditek · 2025 · vol. 31(2) · doi:10.36452/jkdoktmeditek.v31i2.3479 · W4408392495
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This case series explored the clinical presentation, risk factors, and management of subcutaneous endometriosis, finding it often linked to cesarean sections and effectively treated with hormonal therapy or surgery.

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This serial case study from Cipto Mangunkusumo Hospital (January 2022–December 2024) examined the clinical presentation, risk associations, management, and outcomes of seven patients with subcutaneous endometriosis, with data on demographics, prior cesarean section history, history of endometriosis, nodule size, symptoms, treatment approach, and results. Most nodules were located mainly in the cesarean scar, varied in size, and caused significant pain (VAS 5–6); three patients received dienogest therapy and reported significant pain reduction, while surgical management was used across different prior cesarean histories. The authors note a diagnostic challenge because extrapelvic subcutaneous lesions can mimic keloid or fibroma, and they emphasize multidisciplinary management, including plastic surgery, with the goal of aesthetic outcomes and recurrence prevention. This paper is centrally about endometriosis — subcutaneous endometriosis after cesarean scar, including clinical presentation and treatment outcomes (with an associated finding of diffuse adenomyosis in some patients).

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Abstract

Introduction: Subcutaneous endometriosis is a rare condition with endometrial tissue localized outside the pelvis and often mimics general endometriosis. The novelty of this study is an in-depth understanding of the specific risk factors associated with subcutaneous endometriosis after cesarean section and how optimal therapeutic approaches can provide better outcomes in patients with a history of endometriosis. This study aims to explore the clinical presentation, outcomes, and managerial approaches to this condition, as well as provide evidence-based recommendations for its management. Case Illustration: This study involved seven patients at Cipto Mangunkusumo Hospital (January 2022–December 2024). Data collected included demographics, age, BMI, initial symptoms, time of symptom onset, history of cesarean section, history of endometriosis, complications, nodule size, therapeutic approaches, and clinical outcomes. Discussion: Of the seven patients, three underwent one cesarean section, two underwent two operations, and two underwent more than two cesarean sections. A history of diffuse adenomyosis was found in three patients. Subcutaneous nodules located mainly in the cesarean scar, had highly variable sizes and caused significant pain (VAS 5–6). Dienogest therapy was given to three patients and significantly reduced pain. Conclusion:Subcutaneous endometriosis is often associated with a history of abdominal surgery, especially cesarean section. Extrapelvic location can be mistaken for keloid or fibroma, which hinders timely diagnosis. The novelty of this study lies in emphasizing the importance of multidisciplinary collaboration in the management of subcutaneous endometriosis, especially involving plastic surgeons to improve aesthetic results and prevent recurrence. Treatment involving hormonal therapy or surgery, based on the size and location of the nodule, is essential for optimal results
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Introduction

Subcutaneous endometriosis is a rare condition with endometrial tissue localized outside the pelvis and often mimics general endometriosis. The novelty of this study is an in-depth understanding of the specific risk factors associated with subcutaneous endometriosis after cesarean section and how optimal therapeutic approaches can provide better outcomes in patients with a history of endometriosis. This study aims to explore the clinical presentation, outcomes, and managerial approaches to this condition, as well as provide evidencebased recommendations for its management. Case Illustration: This study involved seven patients at Cipto Mangunkusumo Hospital (January 2022–December 2024). Data collected included demographics, age, BMI, initial symptoms, time of symptom onset, history of cesarean section, history of endometriosis, complications, nodule size, therapeutic approaches, and clinical outcomes. Discussion: Of the seven patients, three underwent one cesarean section, two underwent two operations, and two underwent more than two cesarean sections. A history of diffuse adenomyosis was found in three patients. Subcutaneous nodules located mainly in the cesarean scar, had highly variable sizes and caused significant pain (VAS 5–6). Dienogest therapy was given to three patients and significantly reduced pain. Conclusion:Subcutaneous endometriosis is often associated with a history of abdominal surgery, especially cesarean section. Extrapelvic location can be mistaken for keloid or fibroma, which hinders timely diagnosis. The novelty of this study lies in emphasizing the importance of multidisciplinary collaboration in the management of subcutaneous endometriosis, especially involving plastic surgeons to improve aesthetic results and prevent recurrence. Treatment involving hormonal therapy or surgery, based on the size and location of the nodule, is essential for optimal results.

References

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