Association between XRCC3 exon 7 (rs861539) gene polymorphism and micronuclei frequency in medical radiation workers

Association between XRCC3 exon 7 (rs861539) gene polymorphism and micronuclei frequency in medical radiation workers | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 21 November 2025 V1 Latest version Share on Association between XRCC3 exon 7 (rs861539) gene polymorphism and micronuclei frequency in medical radiation workers Authors : Burhannudin , Harry N.E. Surniyantoro , and Nadya Sari 0009-0002-8090-8926 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.176375354.47784781/v1 133 views 44 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The effectiveness of DNA damage repair is affected by the XRCC3 exon 7 polymorphism (rs861539). Ionizing radiation causes micronuclei (MN), which indicate chromosomal abnormalities. This study investigated the relationship between the XRCC3 exon 7 gene polymorphism, gender, age, and equivalent dose (mSv) on MN frequency in medical radiation workers. Multiple Indonesian hospitals provided 35 medical radiation workers and 62 non-medical worker controls for the study. The XRCC3 gene exon 7 polymorphism and MN assay were genotyped using PCR-RFLP and CBMN test. The study found no significant difference in MN frequency between medical radiation workers with mutant genotypes and controls (20.29±2.98 vs. 18.50±6.22; P = 0.512). A significant difference in MN frequency was found between medical radiation workers and controls (P=0.034), with females having a 1.254 times greater likelihood of MN in the control group (P<0.001). Equivalent dose and age did not affect MN frequency. This study found no connection between the XRCC3 exon 7 gene polymorphism and MN prevalence in medical radiation workers. Male gender affects MN frequency in medical radiation workers. DNA repair gene polymorphisms and non-genetic factors, including smoking, alcohol, and lifestyle, should be studied to determine MN frequency in medical radiation workers. Ethical clearance for this research was granted by the Ministry of Health of the Republic of Indonesia under approval number LB.02.01/5.2/KE.171/2016. Supplementary Material File (emm_nadya sari.docx) Download 82.80 KB Information & Authors Information Version history V1 Version 1 21 November 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords dna repair gene gene polymorphism medical radiation workers micronuclei xrcc3 exon 7 Authors Affiliations Burhannudin Poltekkes Kemenkes Jakarta III View all articles by this author Harry N.E. Surniyantoro Badan Riset dan Inovasi Nasional Republik Indonesia View all articles by this author Nadya Sari 0009-0002-8090-8926 [email protected] Poltekkes Kemenkes Jakarta III View all articles by this author Metrics & Citations Metrics Article Usage 133 views 44 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Burhannudin, Harry N.E. Surniyantoro, Nadya Sari. Association between XRCC3 exon 7 (rs861539) gene polymorphism and micronuclei frequency in medical radiation workers. Authorea . 21 November 2025. DOI: https://doi.org/10.22541/au.176375354.47784781/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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