Abnormal uterine bleeding and its causes. Literature review

L. Vygivska, Lesia A. Rudenko, O Pliekhova, Igor Yu. Rakytianskyi
In: Polski Merkuriusz Lekarski · 2024 · vol. 52(4) , pp. 457–461 · doi:10.36740/merkur202404112 · PMID:39360728 · W4403113272
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This literature review outlines abnormal uterine bleeding (AUB) as a common, debilitating gynecological issue affecting women's quality of life, with causes including structural abnormalities, extragenital disorders, and various systemic conditions.

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Abstract

Based on the analysis of information from available sources of scientific literature, the article provides an overview of the problem of abnormal uterine bleeding and its causes. Preservation of women's reproductive health is an urgent problem of the whole world. AUB is a debilitating symptom that affects a large number of women and one of the most common gynecological abnormalities. АUB, as a rule, does not threaten a woman's life, but significantly decreases its quality. Menstrual disorders affect all aspects of a woman's life, even increasing the risk of premature death. Women with AUB are more likely to seek medical care due to social and physical factors, while 50% of female patients have mental health problems due to anxiety and depression. Structural causes of uterine bleeding increase as a woman ages, which can affect reproductive health. Extragenital disorders are considered one of the most frequent causes of AUB. This is explained by the features of the endometrium, the state of which is influenced by general changes in a woman's hormonal status and the functional state of some organs and systems. AUB can be caused by diseases of the thyroid gland, uncorrected diabetes, obesity, blood coagulation disorders (most often von Willebrand's disease), infectious diseases, certain drugs (corticosteroids, antipsychotic or antiepileptic drugs), climate change and diet, psychological stress, etc. Management of patients with abnormal uterine bleeding is a complex problem that should include assessment of gynecological status and consultation of related specialists (endocrinologists, cardiologists, etc.).

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