In vitro radical scavenging and in vivo anti-ulcer and analgesic activities of a metal-curcumin complex.

The present research aimed to study the in vitro radical scavenging activity, anti-ulcer, and analgesic activity of a metal-curcumin complex (MCC) using different models in mice and rats. The antioxidant activity was determined using DPPH free radical scavenging assay, FRAP assay, and ABTS radical cation scavenging assay. MCC showed an effective radical scavenging activity. Trolox was used as a standard in all three assays. Radical scavenging activity was compared with curcumin, showing that MCC was a more effective radical scavenger than curcumin. The anti-ulcerogenic effect was determined using the ethanol-induced method in Sprague Dawley rats, and it showed that MCC was able to produce gastroprotection at an oral dose of 100 mg/kg body weight (b.w). Further, we have also analyzed the analgesic potential of MCC. Analgesic activity of MCC was recorded using the hot plate method in Swiss albino mice. MCC exhibited analgesic activity at an oral dose of 50 mg/kg b.w. As a result, MCC may be beneficial in treating inflammatory illnesses.