Genomic perspective on the bacillus causing paratyphoid B fever

Genomic perspective on the bacillus causing paratyphoid B fever | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Genomic perspective on the bacillus causing paratyphoid B fever François-Xavier Weill, Lise Frézal, Alicia Tran-Dien, Anna Zhukova, and 29 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4502330/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 10 Dec, 2024 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Abstract Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). Here, we provide a genomic overview of the population structure, geographic distribution, and evolution of SPB PG1 by analysing genomes from 568 historical and contemporary isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB . This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB. Health sciences/Diseases/Infectious diseases/Bacterial infection Biological sciences/Microbiology/Bacteria/Bacterial genomics Biological sciences/Microbiology/Bacteriology Full Text Additional Declarations There is NO Competing Interest. Supplementary Files NMICROBIOL24051349ASOM.pdf Supplementary Information NMICROBIOL24051349ASupplementaryData1.xlsx Dataset 1 NMICROBIOL24051349ASupplementaryData2.xlsx Dataset 2 NMICROBIOL24051349ASupplementaryData3.xlsx Dataset 3 NMICROBIOL24051349ASupplementaryData4.xlsx Dataset 4 NMICROBIOL24051349ASupplementaryData5.xlsx Dataset 5 NMICROBIOL24051349ASupplementaryData6.xlsx Dataset 6 NMICROBIOL24051349ASupplementaryData7.xlsx Dataset 7 NMICROBIOL24051349ASupplementaryData8.xlsx Dataset 8 NMICROBIOL24051349ASupplementaryData9.xlsx Dataset 9 Cite Share Download PDF Status: Published Journal Publication published 10 Dec, 2024 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4502330","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":310587170,"identity":"a51f9649-fd06-4c1f-907a-37ca72c7ceca","order_by":0,"name":"François-Xavier 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fever","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"nature-portfolio","isNatureJournal":true,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"","title":"Nature 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Here, we provide a genomic overview of the population structure, geographic distribution, and evolution of SPB PG1 by analysing genomes from 568 historical and contemporary isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of \u003cem\u003egyrA\u003c/em\u003e and \u003cem\u003egyrB\u003c/em\u003e. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.\u003c/p\u003e","manuscriptTitle":"Genomic perspective on the bacillus causing paratyphoid B fever","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-06-18 13:41:08","doi":"10.21203/rs.3.rs-4502330/v1","editorialEvents":[],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"nature-communications","isNatureJournal":true,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"NCOMMS","sideBox":"Learn more about [Nature Communications](http://www.nature.com/ncomms/)","snPcode":"","submissionUrl":"https://mts-ncomms.nature.com/","title":"Nature Communications","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature Communications","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"b91b6855-0f35-4662-9f78-9fd70397dc13","owner":[],"postedDate":"June 18th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":32823066,"name":"Health sciences/Diseases/Infectious diseases/Bacterial infection"},{"id":32823067,"name":"Biological sciences/Microbiology/Bacteria/Bacterial genomics"},{"id":32823068,"name":"Biological sciences/Microbiology/Bacteriology"}],"tags":[],"updatedAt":"2024-12-11T08:06:06+00:00","versionOfRecord":{"articleIdentity":"rs-4502330","link":"https://doi.org/10.1038/s41467-024-54418-4","journal":{"identity":"nature-communications","isVorOnly":false,"title":"Nature Communications"},"publishedOn":"2024-12-10 05:00:00","publishedOnDateReadable":"December 10th, 2024"},"versionCreatedAt":"2024-06-18 13:41:08","video":"","vorDoi":"10.1038/s41467-024-54418-4","vorDoiUrl":"https://doi.org/10.1038/s41467-024-54418-4","workflowStages":[]},"version":"v1","identity":"rs-4502330","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4502330","identity":"rs-4502330","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}