Research Article CYP2C19*3 polymorphism in patients with endometriosis

Inês Bento, K.S.F. e Silva, K.K.V.O. Moura, C.L. Ribeiro Júnior, Iasmim Ribeiro da Costa
In: Genetics and Molecular Research · 2019 · vol. 18(2) · doi:10.4238/gmr18199 · W2943543037
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This study found a significantly higher prevalence of the CYP2C19*3 polymorphism in women with endometriosis compared to healthy controls.

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Abstract

Endometriosis is a pathology that affects women in Brazil and around the world. It is characterized by the presence of endometrial cells outside the uterine cavity, leading to chronic pain, infertility and hormonal cycle deregulations. Ectopic endometrial foci may be responsible for changes in anatomy, in hormonal metabolism, immune and inflammatory systems and the pelvic peritoneum, causing pain and infertility. CYP2C19 is an important gene of the cytochrome p450 family that encodes an aromatase associated with estrogen metabolism. The CYP2C19*3 polymorphism is related to a higher susceptibility for endometriosis in women. This gene is overexpressed in chronic inflammation. The CYP2C19 gene is associated with drug metabolism, detoxification of potential carcinogenic agents and steroid metabolism . We analyzed the prevalence of the CYP2C19*3 polymorphism in women with endometriosis. The control group comprised 14 health women and the case group 19 patients with endometriosis. We found that the CYP2C19*3 polymorphism at a significantly higher rate in endometriosis patients. No individual in the control group presented I. A. Bento et al. 2 had this polymorphism and we found no association between this polymorphism and any social habits in patients with endometriosis.

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Condition tags

endometriosisinfertility

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