Expression of oct-4 and c-kit antigens in endometriosis
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Ectopic epithelial cells in severe endometriosis lesions express oct-4 and c-kit, suggesting a stem cell origin for the ectopic endometrium and potential progression to ovarian cancer.
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Abstract
The objective of this study was to test the expression of the oct-4 and c-kit, both markers of stem cells, in the ectopic endometrial tissue of endometriotic lesions of women with severe endometriosis. Our findings show that ectopic epithelial cells express oct-4 and c-kit and this suggests that the ectopic endometrium in endometriosis has a stem cell origin and could explain the possible progression to ovarian cancer.
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- europepmc
- last seen: 2026-06-18T06:15:08.409253+00:00
- pubmed
- last seen: 2026-05-13T22:16:54.825375+00:00
- unpaywall
- last seen: 2026-05-14T19:30:52.867331+00:00
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine