Evaluation of Serum CA125 and EmAb in Relation to Endometriosis in Different Locations

Objective: To evaluate the relationship between serum CA125 or EmAb levels and endometriosis in different locations.Methods: Ninety-six patients who had been diagnosed by laparoscopy or laparotomy with endometriosis and forty control women without endometriosis were included in this study.Three groups were divided according to the different locations of endometriosis as: Group A,ovarian endometriosis,42 cases;Group B,pelvic endometriosis,40 cases;Group C,scar endometriosis,14 cases.Group D was the control group.The serum CA125 levels and EmAb assay were measured by enzyme-linked immunosorbent assay.Results: The serum CA125 levels in ovarian endometriosis were higher than those in control women(P0.05).The serum CA125 levels in pelvic endometriosis and scar endometriosis were lower than those in ovarian endometriosis(P0.05).The positive rate(sensitivity) of serum CA125 and EmAb was 69.04% and 45.23% respectively in ovarian endometriosis,45.00% and 32.50% respectively in pelvic endometriosis,42.85% and 28.57% respectively in scar endometriosis.And the specificity for CA125 and EmAb was 95% and 97.5% respectively.When both CA125 and EmAb assay were positive,the specificity was 100%.Conclusion: The serum CA125 and EmAb testing for the diagnosis of endometriosis has considerable value.Combined determination of serum CA125 and EmAb can achieve good specificity for the diagnosis of endometriosis.