A DOUBLE BLIND COMPARATIVE STUDY OF CENTCHROMAN WITH EVENINGPRIMEROSE OIL IN THE MANAGEMENT OF MASTALGIA IN BENIGN BREASTDISEASE

INTRODUCTION- Pain is the most common reason for referral to a breast clinic and accounts for up to 50 per cent of patients seen. It is, however, the least understood of all breast symptoms, and the one whose management causes the most controversy. It must be stressed that mastalgia is a symptom and does not imply any specic pathological process. There is considerable debate about drug of choice for management of mastalgia. We present our results of a trial of antiestrogen drug “Centchroman”. The objective of the study was to evaluate the effectiveness of Centchroman in control of mastalgia measured by visual analogue scale (VAS), and compare it with that of Danazol. OBJECTIVES- To evaluate the efcacy, side effect, cost effectiveness of Centchhroman versus Danazol and Evening Primrose Oil in regression of mastalgia in benign breast diseases. PROCEDURE-The study was carried out on 105 patients with mastalgia diagnosed as benign breast disease with VAS score ≥3 lasting for more than 7 days per cycle are included in this study and divided into 3 groups and the study conducted. CONCLUSION- From this study it can be concluded that Centchroman is very cost effective , efcacious with minimal side effect for treatment of mastalgia in beningn breast disease. Although a longer follow up period is necessary to prove its long term efcacy