COX–2 und Neoangiogenese in Endometrioseläsionen

The study investigated whether cyclooxygenase-2 (COX–2) expression in endometriosis lesions is associated with angiogenesis markers, by examining COX–2 and VEGF-A immunohistochemically in 32 peritoneal, 21 ovarian, and 17 rectovaginal endometriosis lesions, and assessing vascular status using immunofluorescence for von Willebrand factor (vWF) and smooth muscle actin (sma). COX–2 and VEGF-A were expressed in epithelial cells at high frequencies (93.1% and 96.2%), and there was a significant positive correlation between COX–2 and VEGF-A expression (p=0.009). In lesions with strong COX–2 and VEGF-A expression, the authors observed neoangiogenesis characterized by immature vessels that were vWF-positive but sma-negative, consistent with endothelial cells without smooth muscle cells. This paper is centrally about endometriosis — specifically the relationship between COX–2 expression, VEGF-A, and neoangiogenesis in endometriotic lesions.

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