The vaginal microbiome drives endometriosis pain
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Endometriosis-associated vaginal dysbiosis is sufficient to induce pain in a mouse model, and antibiotic treatment or microbiome transplant reverses this pain.
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Abstract
Despite being one of two cardinal disease symptoms, endometriosis pain is poorly understood. Using a validated mouse model, we demonstrate that endometriosis-associated vaginal dysbiosis is sufficient to induce pain in the absence of disease pathology. In addition, intravaginal antibiotic treatment and vaginal microbiome transplant from healthy control animals reverses pain in endometriosis mice.
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- europepmc
- last seen: 2026-09-03T06:35:27.962359+00:00
- pmc
- last seen: 2026-05-13T20:22:03.195721+00:00
- pubmed
- last seen: 2026-09-03T06:10:59.236663+00:00
- unpaywall
- last seen: 2026-05-11T08:34:28.763810+00:00
License: public-domain-us
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine