Danazol and Ketotifen in a Refractory Cholinergic Urticaria: Case Report

Cholinergic urticaria (ChU) is a type of induced urticaria characterized by small and pruritic wheals which are triggered by specific stimuli such as physical exercise thus significantly impairing the quality of life. The goal of treatment is to ensure prompt and prolonged control of symptoms, thus enabling the return to normal social activities. The traditional options are antihistamines, leukotriene inhibitors and immunosuppressive agents. We present a case of refractory cholinergic urticaria who had an adequate response to danazol and ketotifen. Evaluating it by number of wheals, quality of life (Dermatology Life Quality Index (DLQI)), severity of pruritus (12-Item Pruritus Severity Score (12-PSS)) and pulse controlled, thereby proving to be an effective therapy in patients who don´t respond to conventional therapy and without access to biological treatment.