Состояние системного и местного иммунитета при наружном генитальном эндометриозе в зависимости от наличия или отсутствия возбудителей генитальной инфекции

The aim of the research is to compare the indices of systemic and tissue immunity in 130 female patients with endometriosis genitalis externa (EGE) depending on present or absent genital infectious agents in endocervix, endometrium, peritoneal fluid and endometriosis foci. The PCR method showed the maximum incidence of Ureaplasma spp., HPV and their combinations. The indices of system immunity in female patients with endometriosis genitalis externa and present genital infectious agents were characterized: at stage I with reduced peripheral blood percentage of T-lymphocytes, T-helpers, immunoregulatory balance, HCT-spontaneous activity of neutrophils; increased percentage NK-lymphocytes, absolute count of cytotoxic cells and IgG; at stage II – increased circulating immune complex; at stage III – increased percentage of T-lymphocytes, T-helpers and decreased percentage of T-NK lymphocytes; at stage IV we observed increased immunoregulatory index. The peritoneal fluid in I stage female patients with present genital infectious agents had decreased HCT-spontaneous activity of peritoneal macrophages, at II stage we observed increased phagocytic activity of neutrophils and macrophages, HCT-spontaneous activity of macrophages, at III and IV stages – decreased count of white blood cells, increased count of living cells, lysosomal activity of neutrophils and macrophages, HCT-induced activity of macrophages.